This literature survey of the medical treatment of venous ulcers of the lower extremities discusses five classes of agents: (1) fibrinolytics, (2) hydroxyrutosides, (3) prostaglandins, (4) methylxanthines, and (5) others. The authors conclude that all these agents require further research.
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References
1.
Nicholls R.: Venous and arterial leg ulcers: A literature review. Care Science and Practice7:105, 1989.
2.
Callam MJ, Ruckley CV, Harper DR, et al: Chronic ulceration of the leg: Extent of the problem and provision of care. Br Med J290:1855-1856, 1985 .
3.
Harkiss KJ: Cost analysis of dressing material used in venous leg ulcers. Pharm J235:268-269, 1985.
4.
Harper DR, Ruckley CV, Dale JJ, et al: A clinical trial of elastic versus minimal stretch bandaging and hydrophilic foam versus knitted dressings in venous leg ulcers. Proceedings of the Fifth European American Symposium on Venous Disease, Vienna, 1990.
5.
Northeast Adr, Layer GT, Browse NL, et at: Higher compression increases venous ulcer healing rates. Proceedings of the Fifth European American Symposium on Venous Disease, Vienna, 1990.
Browse NL, Jarrett Pem, Morland M., et al: Treatment of liposclerosis of the leg by fibrinolytic enhancement: A preliminary report. Br Med Jii:434-435, 1977.
8.
Bumand K., Lemenson G., Morland M., et al: Venous lipodermatosclerosis: Treatment by fibrinolytic enhancement and elastic compression. Br Med J280:7-11, 1980.
9.
Layer GT, Stacey MC, Bumand KG: Stanozolol and the treatment of venous ulceration—an interim report . Phlebology1:197-203, 1986.
10.
Belcaro G., Marelli C.: Treatment of venous lipodermatosclerosis and ulceration in venous hypertension by elastic compression and fibrinolytic enhancement with defibrotide. Phlebology4:91-106, 1989.
11.
Neumann Ham , van den Broek Mjtb: Evaluation of O-(B-hydroxyethyl)-rutosides in chronic venous insufficiency by means of noninvasive techniques. Phlebology5(suppl):13-20, 1990.
12.
DeJongste AB , Jonker Jjc, Huisman MV, et al: A double-blind trial on the short-term efficacy of HR in patients with post-thrombotic syndrome. Phlebology5(suppl):21-22, 1990.
13.
Stegmann W. , Huebner K., Deichmann B., et al: Wirksamkeit der O-(beta-hydroxyethyl)-rutoside bei der behandlung des venosen Ulcus cruris. Therapiewoche36:1828-1833, 1986.
14.
Diehm C., Kuhn A., Strauss R., et al: Effects of regular physical training in a supervised class and additional intravenous prostaglandin E, and naftidrofuryl infusion therapy in patients with intermittent claudication—a controlled study. VASA28(suppl):26-30, 1989.
15.
Balzer K., Rogatti W., Ruttgerodt K.: Efficacy and tolerability of intra-arterial and intravenous prostaglandin E, infusions in occlusive arterial disease stage III/IV. VASA28(suppl):31-38, 1989.
16.
Beitner H., Hammar H., Olsson AG, et al: Prostaglandin E, treatment of leg ulcers caused by venous or arterial incompetence. Acta Dermatovener60:425-430, 1980.
17.
Rudofsky G.: Intravenous prostaglandin E, in the treatment of venous ulcers—a double-blind, placebo-controlled trial. VASA28(suppl):39-43, 1989.
18.
Weitgasser H. : The use of pentoxifylline ("Trental" 400) in the treatment of leg ulcers: Results of a double-blind trial. Pharmatherapeutica3(suupl):143-151, 1983.
19.
Colgan MP, Dormandy JA, Jones PW, et al: Oxpentifylline treatment of venous ulcers of the leg. Br Med J300:972-975, 1990.
20.
Ehrly AM, Schenk J., Bromberger U.: Venous leg ulcers: Microcirculatory improvement with low-dose, long-term Urokinase therapy. Proceedings of the Fifth European American Symposium on Venous Disease, Vienna, 1990.