Myocardial Infarction Complicating Postsplenectomy Thrombocytosis,with Early Left Ventricular Mural Thrombus Formation and Cerebral Embolism— A Case Report
Restricted accessResearch articleFirst published online January, 1993
Myocardial Infarction Complicating Postsplenectomy Thrombocytosis,with Early Left Ventricular Mural Thrombus Formation and Cerebral Embolism— A Case Report
Thrombocytosis is a rare cause of ischemic cardiovascular and cerebrovascular events in patients with intrinsically normal coronary and cerebral vasculature. This report details the occurrence of inferior wall myocardial infarction (MI) consequent upon postsplenectomy thrombocytosis in a thirty-four-year-old man with angiographically normal coronary arteries. The MI was complicated by early left ventricular mural thrombus formation and embolic cerebral infarction. Combined anticoagulant and antiplatelet therapy was required to prevent the recurrence of ischemic events.
Get full access to this article
View all access options for this article.
References
1.
Lindsay Jr, Pichard AD: Acute myocardial infarction with normal coronary arteries. Circulation54:902-904, 1984.
2.
Arnett EN, Roberts WC: Acute myocardial infarction and angiographically normal coronary arteries: An unproven combination (editorial). Circulation53:395-400, 1976.
3.
Glover MU, Kuber MT, Warren SE, et al: Myocardial infarction before age 36: Risk factor and arteriographic analysis. Am J Cardiol49:1600-1603, 1982 .
4.
Rosenblatt A. , Selzer A.: The nature and clinical features of myocardial infarction with normal coronary angiogram. Circulation55:578-580, 1977.
5.
Schuster EH, Achuff SC, Bell MR, et al: Multiple coronary thromboses in previously normal coronary arteries: A rare cause of acute myocardial infarction. Am Heart J99:506-509, 1980.
6.
Rapold HJ, Haeberli A., Kuemmerli H., et al: Fibrin formation and platelet activation in patients with myocardial infarction and normal coronary arteries. Eur Heart J10:323-333, 1989.
7.
Schafer AI: The hypercoagulable states. Ann Intern Med102:814-828, 1985.
8.
Douste-Blazy P., Taudou MJ, Delay M., et al: Essential thrombocythemia and recurrent myocardial infarction (letter). Lancetii:992, 1984.
9.
Host HB, Hasselbach H., Feldt-Rasmussen B.: Myocardial infarction before the age of twenty is rare (letter). Eur J Hematol41:511, 1988.
10.
Buss DH, Stuart JJ, Lipscomb GE: The incidence of thrombotic and hemorrhagic disorders in association with extreme thrombocytosis: An analysis of 129 cases. Am J Hematol20:365-372, 1985.
Delangre T. , Mihout B., Borh JY, et al: Primary thrombocythemia in a patient with cerebellar infarction. Stroke16:524-526, 1985.
13.
Grisell DL, Mills GM: Reversible acute sensorineural hearing loss associated with essential thrombocytosis . Arch Intern Med146:1813, 1986 .
14.
Bernard PG: Neurologic complications of thrombocythemia: Six cases and review . Va Med114:352-355, 1987.
15.
Heller DS, Pervez NK, Kleinerman J.: Fatal cerebrovascular thrombosis in a young woman: An unusual complication associated with hypochromic anemia and thrombocytosis following surgery. Mt Sinai J Med55:318-320, 1988.
16.
Naranjo IC, Gonzalez RM, Rieger JS, et al: Transient ischemic attacks associated with thrombocytosis in active rheumatoid arthritis (letter). J Neurol Neurosurg Psychiatry51:1599,, 1988.
17.
Katz VL, Cefalo RC: Maternal death from carotid artery thrombosis associated with the syndrome of hemolysis, elevated liver function, and low platelets. Am J Perinatol6:360-362, 1989.
18.
McDonald TD , Tatemichi TK, Kranzler SJ, et al: Thrombosis of the superior sagittal sinus associated with essential thrombocytosis followed by MRI during anticoagulant therapy. Neurology39:1554-1555, 1989 .
19.
Wong V., Yu YL, Liang Rhs, et al: Cerebral thrombosis in β-thalassemia/hemoglobin E disease . Stroke21:812-816, 1990.