Capillary filtration (CF) was assessed in 43 patients with venous hypertension and in 10 normal subjects by means of strain gauge plethysmography. The patients were then divided into two treatment groups; 22 were treated with Daflon, 500 mg tid, and 21 with Daflon, 500 mg bid. The normal subjects were also treated (500 mg tid).
After four weeks CF was significantly decreased in all subjects, the decrease being higher in the high-dose groups. CF did not significantly change in normal subjects. In conclusion Daflon decreases CF in subjects with venous hypertension and the CF decrease is dose related.
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References
1.
Belcaro G., Rulo A., Vasdekis S., et al: Combined evaluation of postphlebitic limbs by laser-Doppler flowmetry and transcutaneous PO2-PCO2 measurements. VASA4:259-263, 1988.
2.
Belcaro G., Christopoulos D., Nicolaides AN: Skin flow and swelling in postphlebitic limbs. VASA18:136-139, 1989.
3.
Guillot B., Guilhou JJ, De Champvallins M, et al: A long term treatment with a venous drug—results on efficacy and safety of Daflon 500 mg in chronic venous insufficiency. Int Angiol8(Suppl 4):67-71, 1989.
4.
Godfraint T. : Effect of a flavonoid preparation (S 5682) on experimental capillary permeability increase in rat paws and rabbit skin . Int Angiol7:17-19, 1988.
5.
Behar A., Lagrue G., Cohen-Boulakia F., et al: Study of capillary filtration by double labelling I131-albumin and Tc99 reds. Application to the pharmacodynamic activity of Daflon 500. Int Angiol7:35-38, 1988.
6.
Nicolaides AN , Zukowsky AJ: The value of dynamic venous pressure measurements . World J Surg10:919-923, 1986.
7.
Thulesius O. : Capillary filtration under normal and pathological conditions. Angiologica10: 198, 1973.
8.
Belcaro G.: Flussimetria laser-Doppler e Microcircolazione. Torino : Ed. Minerva Medica, cap.VII:55-67, 1989.
9.
Fagrell B.: Microcirculatory disturbances—the final cause for venous leg ulcers . VASA11:101-110, 1982.
