Is Sublingual Nifedipine Administration Superior to Oral Administration in the Active Treatment of Hypertension?

Abstract

Nifedipine, a calcium-channel-blocking agent, was administered orally to 44 untreated patients (Group A) and sublingually to 51 untreated patients (Group B) who had a diastolic blood pressure more than 90 mm Hg and systolic blood pressure more than 140 mm Hg. The mean pretreatment systolic and diastolic blood pressure values were 185.3 ± 26.0 and 115.1 ± 13.4 mm Hg in Group A patients and 193.6 ± 23.1 and 118.1 ± 14.1 mm Hg in Group B patients respectively (p >0.05). The hypotensive activity of nifedipine was observed at the tenth minute in both groups. Mean systolic and diastolic pressures were 168.9 ± 23.7 and 101.9 ± 14.2 mm Hg in Group A and 170.6 ± 26.2 and 103.0 ± 15.8 mm Hg in Group B, (p < 0.001) Diastolic blood pressures dropped under 100 mm Hg at the twentieth minute in both groups. Maximal reduction of blood pressure was observed at the fortieth minute in both groups and the degree of reduction in blood pressure was also the same (mean systolic and diastolic blood pressures: 143.7 ± 22.1 and 86.9 ± 11.7 in Group A and 148.7 ± 21.4 and 91.7 ± 17.0 in Group B (p >0.05)

The authors conclude that sublingual nifedipine administration is not supe rior to oral nifedipine administration (in capsular form) in the acute treatment of hypertension.