An eighty-one-year-old woman received quinidine in order to convert atrial fibrillation to a sinus rhythm. The patient developed a prolonged QT interval on the EKG, as well as episodes of torsade de pointes. With the administration of intravenous magnesium sulfate, the abnormal rhythm was suppressed within minutes. Thus, magnesium should be the first drug used in patients with torsade de pointes and prolonged QT interval on the electrocardiogram.
Get full access to this article
View all access options for this article.
References
1.
Perticone F. , Adinolfi L., Bonaduce D.: Efficacy of magnesium sulfate in the treatment of torsade de pointes. Am Heart J112:847-, 1986 .
2.
Tzivoni D., Keren A., Cohen AM, et al: Magnesium therapy for torsade de pointes. Am J Cardiol53:528-, 1984.
3.
Topol EJ, Lerman BB: Hypermagnesemic torsade de pointes. Am J Cardiol52:1367-, 1983.
4.
Rasmussen HS , Thomsen, Peb: The electrophysiological effects of intravenous magnesium on human sinus node, atrioventricular node, atrium and ventricle . Clin Cardiol12:85-, 1989.
5.
DiCarlo LA, Morady F., DeBuiteur, M., et al: Effects of magnesium sulfate on cardiac conduction and refractoriness in humans. J Am Coll Cardiol7:1356-, 1986.
6.
Kay GN, Plumb VJ, Arciniegas JG, et al: Torsade de pointes: The long short initiating sequence and other clinical features—observations in 32 patients. J Am Coll Cardiol2:806-, 1983.
7.
Kossman CE: Torsade de pointes: An addition to the nosography of ventricular tachycardia . Am J Cardiol42:1054-, 1978.
8.
Schechter E. , Fredmand CC, Lazzara R.: After depolarization as a mechanism for long QT syndrome: Electrophysiologic studies of a case. J Am Coll Cardiol3:1556-, 1984.
9.
Tsien RW, Carpenter OD: Ionic mechanism of pacemaker activity in cardiac Purkinje fibers. Fed Proc37:2127-, 1978.
10.
Kass RS, Ledever WJ, Tsien RW, et al: Rate of calcium loss in transient inward currents and after contractions induced by strophanthidine in cardiac Purkinje fibers. J Physiol281:187, 1978.