Nifedipine was administered orally to 2 patients with primary hyperparathy roidism before and after parathyroidectomy. The operation lowered serum cal cium concentration and parathyroid hormone but did not alter plasma renin activity, plasma aldosterone concentration, and serum magnesium. The hypo tensive effects of nifedipine were markedly enhanced with the decrease in serum calcium concentration following parathyroidectomy. Thus, the level of serum calcium concentration may modulate the hypotensive effect of nifedipine in hu mans.
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References
1.
Frohlich ED: Hemodynamic effects of calcium entry blocking agents in normal and hypertensive rats and man. Am J Cardiol56:21H-27H, 1985.
2.
Fleckenstein A.: History of calcium antagonists. Circ Res52 (Suppl I):3-16, 1983.
3.
Resnick LM, Nicholson JP, Largh JH: Calcium metabolism in essential hypertension: Relationship to altered renin system activity. Fed Proc45:2739-2745, 1986.
4.
Rambausek M. , Ritz E., Rascher W., et al: Vascular effects of parathyroid hormone (PTH). Adv Exp Med Biol151:619-632, 1982.
5.
Lang J., Timour-Chah Q., Chelby ME, et al: Effect of gradual rise in plasma calcium concentration on the impairment of atrioventricular nodal conduction due to verapamil. J Cardiovasc Pharmacol8:6-13, 1986.
