Precordial ECG Mapping in Acute Myocardial Infarction (AMI) After Intravenous Infusion of Streptokinase (s)

Abstract

Repeated precordial ECG map ping (42 leads) and CK-MB serum measurements were done in 40 pa tients with anterior and/or antero lateral acute myocardial infarction. Twenty patients serving as controls, were treated with routine anticoagu lant therapy. In 20 patients (the s group), randomly selected, a short- term IV infusion of 1,500,000 IU streptokinase was administered and followed by the same anticoagulant treatment as in controls. Ten subjects from each group underwent coronary arteriography one month later.

From the analysis of ECG map ping the number of leads (N) and the sum of measurements (Σ) for each parameter were calculated. Before treatment there were no significant differences for all measured parame ters between the two groups of pa tients. Seven days later, ST elevations were statistically different for NST and ΣST with lower values for the s group. Higher values for NR and ΣR were also noted in this group. No sta tistically significant difference was found for NQ and ΣQ. CK-MB curve showed an earlier peak in the s group than in the control group. Five pa tients from the s group showed a pa tency of the infarct-related vessel.

In conclusion, the results of this study show that patients receiving s have a significant benefit with ECG improvement. On the other hand, the CK-MB curve indicates an eventual recanalization to a certain degree in the obstructed coronary artery, which is the final goal.