Intravenous naftidrofuryl has been shown to improve transcutaneous oxygen pressure values in patients with severe ischemia of the lower limbs who were considered unsuitable for reconstructive surgery. Although it did not alter the outcome in patients with rest pain, the clinical impression is that it afforded symptomatic relief for a period of time. Clinical implications of these findings require further long-term studies.
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References
1.
Wong AL, MacB ain GC: The importance of personality measurement in the assessment of response to treatment for ischemic rest pain. Br J Surg67:509-513, 1980.
2.
Meehan SE, Preece PE, Walker WF: The usefulness of naftidrofuryl in severe peripheral ischemia—asymp— tomatic assessment using linear analogue scales. Angiology33:625-634, 1982.
3.
Raftery AT: A controlled trial of naftidrofuryl (Praxilene) in ischemic rest pain . Br J IV Ther33:7-12, 1982.
4.
Mustapha NM, Redhead RG, Jain SK, et al: Transcutaneous partial oxygen pressure assessment of the ischemic lower limb. Surg Gynecol Obstet156:582-584, 1983.
5.
Byrne P., Provan JL, Ameli FM, et al: The use of transcutaneous oxygen tension measurement in the diagnosis of peripheral vascular insufficiency. Ann Surg200:159-165, 1984.
6.
Dowd Gse, Linge K., Bentley G.: Measurement of transcutaneous oxygen pressure in normal and ischemic skin . J. Bone Joint Surg65:79-83, 1983.
7.
Shaw Swj, Johnson RH: The effect of naftidrofuryl on the metabolic response to exercise in man. Acta Neurol Scand52:231-237, 1975.
