Effects of sublingual administration of nifedipine on systemic arterial pres sure (BP), plasma renin activity (PRA), aldosteron level (AL), and serum so dium (Na) and potassium (K) levels, have been determined. A significant decrease was observed in systolic and diastolic blood pressure five minutes after the sublingual administration of nifedipine in 21 patients with mild or moderate essential hypertension. Furthermore, in an observation period of six hours, it was also established that the effect of nifedipine on systolic and diastolic blood pressure continued. An increase was observed in glomerular filtration rate, whereas there were no changes in PRA, AL, or serum Na and K levels.
Get full access to this article
View all access options for this article.
References
1.
Ames RP, Hill P.: Antihypertensive therapy and the risk of coronary heart disease. J Cardiovasc Pharmacol4:206-212, 1982.
2.
Editorial: Risk of antihypertensive therapy. Lancet8:1075-1076, 1986.
3.
Gilman AG, Goodman LS, et al: The Pharmacological Basis of Therapeutics, ed. 7New York: MacMillan , 1985, pp 665, 816-821.
4.
Olivari MT, Bartorelli C., Gease AP, et al: Treatment of hypertension with nifedipine, a calcium antagonistic agent. Circulation59:1056-1062, 1979 .
5.
Kendall MJ, Dean S.: The use of nifedipine as third line therapy in the treatment of severe hypertension. PostgardMed J59:119-123, 1983.
6.
Heidland A., Heidbreler E., Hörl WH, et al: Calcium antagonisten in der Therapie der Hypertonie. Klin Wochenschr61:633-640, 1983.
7.
Guazzi MD, Cesare N., Galli G., et al: Nitrendipine vs long-acting nifedipine in mild, moderate, and severe hypertension. Angiology37:508-518, 1986.
8.
Aoki K., Kondo S., Mochizuki A., et al: Antihypertensive effect of cardiovascular calcium antagonist in hypertensive patients in the absence and presence of beta-adrenergic blockade . Am Heart J96:218-225, 1978.
9.
Murphy MB, Scriven Ajl, Dolery CT: Role of nifedipine in treatment of hypertension. Br Med J287:257-259, 1983.
10.
Ichiava I., Miele JF, Brenner BM: Reversal of the renal cortical actions of angiotensin II by verapamil and manganese. Kidney Int16:137, 1979.
