Acute effects of coronary vasodilators (nifedipine, nicardipine, and nitroglycerin) on atrial natriuretic peptide (ANP) and the renin-angiotensin-aldosterone system were studied in normal subjects and patients with essential hypertension. Nifedipine lowered blood pressure both in normal subjects and in patients and elevated ANP, plasma renin activity, and angiotensin II in normal subjects but not in hypertensive patients. Nicardipine lowered blood pressure but failed to elevate ANP and angiotensin II in normal subjects. Nitroglycerin failed to elevate ANP in normal subjects.
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References
1.
De Wardner HE , Clarkson EM: Concept of natriuretic hormone. Physiol Rev65:658-759, 1985.
Kohno M., et al: Effects of high-sodium and low-sodium intake on circulating atrial natriuretic peptide in salt-sensitive patients with systemic hypertension . Am J Cardiol59:1212-1213, 1987 .
4.
Kohno M., et al: Circulating atrial natriuretic polypeptide in essential hypertension . Am Heart J113:1160-1163, 1987 .
5.
Klutsch K., Schmidt P., Grosswendt J.: Der Einfluss von Bay a 1040 (nifedipine) auf die Nierenfunktion des Hypertonikers . Arzneim Forsch22:377-380, 1972.
6.
Hiramatsu K. , et al: Acute effects of the calcium antagonist nifedipine on blood pressure, pulse rate, and the renin-angiotensin-aldosterone system in patients with essential hypertension. Am Heart J104:1346-1350, 1982.
7.
Campbell WB, et al: Vasodilating anti-hypertensive drug-induced aldosterone release—a study of endogenous angiotensin-mediated aldosterone release in the rat. J Pharmacol Exp Ther193:166-175, 1975.
8.
Fakunding JL , Chow R., Catt KJ: The role of calcium in the stimulation of aldosterone production by adrenocorticotropin, angiotensin II, and potassium in isolated glomerulosa cells. Endocrinol105:327-333, 1979.
9.
Shima J., et al: Effects of calcium antagonists on the secretion of atrial natriuretic peptide in normal volunteers. Curr Ther Res42:115-123, 1987.
10.
Cuneo RC, et al: Effect of physiological levels of atrial natriuretic peptide on hormone secretion: Inhibition of angiotensin-induced aldosterone secretion and renin release in normal man. J Clin Endocrinol Metab65:765-772, 1987.
