The relationship between periph eral vascular disease (PVD) and plasma apoproteins has still not been well defined. The lipid and apopro tein pattern of a group of 20 normoli pemic patients affected by peripheral vascular disease has been compared with 20 healthy normolipemic sub jects. Mean triglyceride plasma levels were higher in normolipemic patients than in the healthy controls (107.8±31.5 mg% vs 73.3±28.6 mg%; p<0.03) while mean HDL cholesterol values were significantly lower (36.5±5.4 mg% vs 44.4±7.1 mg%; p < 0.003). No significant dif ference was observed between the two groups in the mean values of the apoproteins AI (112.1±41.2 mg% in PVD vs 117.2±17.7 mg% in con trols), All (45.1±12.2 mg% vs 50.1±11.1 mg%), B (93.7±23.5 mg% vs 91.3±21.6 mg%), CII (3.9±2.6 mg% vs 2.6±1.7 mg%), CIII (6.7±1.5 vs 5.9±1.4 mg%) and E (3.09±1.4 mg% vs 3.3±0.9 mg%). On the contrary the mean triglycer ide/Apo-E ratio was higher in PVD patients than in the controls (52.3±42 vs 23.3±10; p<0.03).