A study of platelet aggregation in 324 diabetes mellitus (DM) patients and 24 patients with microvascular complications of DM (retinopathy) is reported. Platelet aggregation tests showed that DM patients can be divided into two groups: "normal" and "prone." The mean reading and standard deviation (SD) of the normal group was found to be 22.6% (SD 6.99%). The mean reading and standard deviation of the prone group was found to be 60.5% (SD 12.7%) re spectively. All patients with microangiopathy had a significant increase, all of them being in the prone range, with a mean of 69.5% (SD 7.2%). Platelet hyper function appears to be a high-risk factor for the development of diabetic mi croangiopathies. A hypothesis postulating platelet hyperfunction as an additional factor along with altered glycoprotein metabolism and explaining the chain of events in the genesis of diabetic microangiopathies is presented.
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References
1.
Rand LI: Recent advances in diabetic retinopathy. Am J Med70:595-601, 1981.
2.
Forster DW: Diabetes mellitus. In: Harrison's Principles of Internal Medicine, ninth edition, ed. by Isselbacher KJ, Adams RD, Braundwald E, et al. Tokyo: McGraw-Hill International Book Co., 1980, pp 1752-1753.
3.
Spiro RG: Glycoproteins and diabetic microangiopathy. In: Joslin's Diabetes Mellitus, eleventh edition, ed. by Marble A, White P, Bradley RF, Krall LP.Philadelphia: Lee & Febiger, 1971, pp 146-156.
4.
Hassanein AA , el-Garf TA, el-Baz Z.: Platelet aggregation in diabetes mellitus and the effect of insulin in vivo on aggregation. Thromb Diath Haemorrh27:114-120, 1972.
5.
Kwaan HC, Colwell JA, Cruz S., et al: Increased platelet aggregation in diabetes mellitus. J Lab Clin Med80:236-246, 1972.
6.
Velaskar DS, Chitre AP: A new aspect of platelet aggregation and a test to measure it. Am J Clin Pathol77:267-274, 1982.
7.
Born Gvr: Aggregation of blood platelets by adenosine diphosphate and its reversal. Nature194:927-929, 1962.
8.
Wu KK, Hoak JC: A new method for the quantitative detection of platelet aggregates in patients with arterial insufficiency. Lancet2:924-929, 1974.
9.
Boyd W.: A Text Book of Pathology—Structure and Function in Disease, eighth edition, ed. by Boyd W.Philadelphia : Lee and Febiger, 1970, pp 920-921.
10.
Vracko: As quoted by Porte D Jr., Halter JB: The endocrine pancreas and diabetes mellitus . In: Textbook of Endocrinology, ed. by Williams RH.Tokyo: Igaku-Shoin /Saunders, 1981, pp 716-843.
11.
Vergese R., Pai KN, Ramchandran P., et al: Microangiopathy in pancreatogenic diabetes. Proc First National Congress on Diabetes, Madras, India, ed. by Visvanathan M, Krishnaswami CV, 1969, pp 297-306.
12.
Porte D. Jr, Halter JB: The endocrine pancreas and diabetes mellitus . In: Textbook of Endocrinology, ed. by Williams RH.Tokyo: Igaku-Shoin /Saunders, 1981, pp 716-843.
13.
Williams RH: The Pancreas. In: Textbook of Endocrinology, ed. by Williams RH.Philadelphia: W.B. Saunders Co., 1962, pp. 574-575.
14.
Wintrobe MM: Clinical Haematology, seventh edition, ed. by Wintrobe MM, Lee GR, Boggs DR, et al. Tokyo: Igaku-Shoin Ltd., 1974, pp 1236-1237.
15.
Harkar LA: Platelets. In: Recent Advances in Haematology II, ed. by Hoffbrand AV, Brain MC, Hirsh J.Edinburgh: Churchill Livingstone, 1977, pp 349-373.
16.
Bierman EL: Atherosclerosis and other forms of arteriosclerosis. In: Harrison's Principles of Internal Medicine, ninth edition, ed. by Isselbacher KJ, Adams RD, Braunwald E, et al. Tokyo: McGraw-Hill International Book Co., 1980, p 1164.
