The authors report 2 patients with vasospastic angina in whom alcohol ingestion was effective in preventing angina. Coronary angiography revealed no organic coronary stenosis but demonstrated coronary artery spasm during angina attacks. In 1 patient, alcohol ingestion every six hours completely suppressed frequent spontaneous angina. In the other patient, alcohol ingestion markedly prolonged the duration of the exercise on treadmill testing by preventing exercise-induced coronary spasm.
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References
1.
Heberden W.: Some account of disorder of breast. Med Trans R Coll Physicians2:59-67, 1786.
2.
Stearns S., Riseman Jef, Gray W.: Alcohol in the treatment of angina pectoris. N Engl J Med234:578-582, 1946.
3.
Russek HI, Naegele CF, Regan FD: Alcohol in the treatment of angina pectoris. JAMA143:355-357, 1950.
4.
Orland, Aronow WS, Cassidy J., et al: Effect of ethanol on angina pectoris . Ann Int Med84:652-655, 1976.
5.
Matsuguchi T. , Araki H., Anan T., et al: Provocation of variant angina by alcohol ingestion. Eur Heart J5:906-912, 1984.
6.
Takizawa A., Yasue H., Omote S., et al: Variant angina induced by alcohol ingestion. Am Heart J107:25-27, 1984.
7.
Oliva PB, Potts DE, Pluss RG: Coronary arterial spasm in Prinzmetal's angina. N Engl J Med288:745-751, 1973.
8.
Yasue H., Touyama M., Kato H., et al: Prinzmetal's variant form of angina as manifestation of alpha-adrenergic receptor mediated coronary artery spasm. Documentation by coronary arteriography . Am Heart J91:148-155, 1976.
9.
Endo M., Hirosawa K., Kaneko N., et al: Prinzmetal's variant angina. Coronary arteriogram and ventriculogram during attack induced by methacholine. N Engl J Med294:252-255, 1976.
10.
Yasue H., Omote S., Takizawa A., et al: Exertional angina pectoris caused by coronary arterial spasm. Effects of various drugs. Am J Cardiol43:647-652, 1979.
11.
Maseri A., Severi S., De Nes M., et al: "Variant" angina: One aspect of a continuous spectrum of vasospastic myocardial ischemia. Am J Cardiol42:1019-1035, 1978.
12.
Shimokawa H. , Matsuguchi T., Koiwaya Y., et al: Variable exercise capacity in variant angina and greater exertional thallium-201 myocardial defect during vasospastic ischemic ST segment elevation than with ST depression. Am Heart J103:142-145, 1982.
13.
Evans W., Hoyle C.: The prevention and treatment of individual attacks of angina pectoris (angina of effort). Quart J Med3:105-135, 1934.
14.
James TN, Bear ES: Effects of ethanol and acetaldehyde on the heart. Am Heart J74:243-255, 1967.
15.
Akabane J., Nakanishi S., Kohei H.: Studies on sympathomimetic action of acetaldehyde. II. Secretory response of the adrenal medulla to acetaldehyde: Experiment with the perfused cat adrenals . Jpn J Pharmacol15:217-222, 1965.
16.
Oyama Y., Akaike N., Nishi K.: Effects of n-alkanols on the calcium current of intracellularly perfused neurons of Helix aspersa. Brain Res376:280-284, 1986.
