Ninety-four patients suffering from venous insufficiency of the lower limbs participated in a multicenter, double-blind versus placebo study. After randomization, they were allotted for a treatment period of two months to one of three groups: TECA 120 mg/day, TECA 60 mg/day, or placebo. A significant difference (p < 0.05) in favor of TECA was shown for the symptoms of heaviness in the lower limbs and edema, as well as for the overall evaluation by the patient. The venous distensibility measured by a mercury strain gauge plethysmograph at three occlusion pressures was improved for the TECA groups but aggravated for the placebo group.
Get full access to this article
View all access options for this article.
References
1.
Max Planck Institute fur Biochimie: Possible influence of Madescassol on synthesis of collagen by human embryonic fibroblasts. Report of a pilot study, April, 1978.
2.
Macquart FX, Bellon G., Brien MA, et al: Titrated extract from Centella Asiatica stimulates collagen biosynthesis by human vein wall fibroblastic cell cultures. Phlebology D. Negus and G. Jantet, John LibbeyLondon, Pain Publishers, pp. 843-845, 1985.
3.
Bouvier CA, Engels E., Grobety J., et al: Aspects métaboliques de la maladie variqueuse—Etude structurelle, histochimique et clinique. Med et Hyg36:1142, 1978.
4.
Pointel JP, Gin H., Drouin P., et al: Venous plethysmography and normal values. Angiology32(3): 145, 191, March, 1981.
5.
Brugmans J., Jacqueneau A., Horig G., et al: Modem technics in venous occlusion plethysmography in the assessment of peripheral vascular disease. Proc Royal Soc70 (Suppl 8):1-6, 1977.
