A single dose of 600 mg of naftidrofuryl perfused IV during three hours in 12 stage III arteriopathic patients did not modify the average blood flow at the calf but did significantly increase transcutaneous oxygen pressure (33 vs 52 mmHg) and also improved lactates (1.44 vs 0.88 mmol/liter), pyruvate (59 vs 79 μmol/liter), and lactates-pyruvates ratio (33.48 vs 20.92).
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References
1.
Ehrly AM, Schroeder W.: Oxygen pressure values in the ischemic muscle tissue of patients with chronic arterial disease. In: Oxygen Transport to Tissue, ed. by Silver IA.New York, Plenum, 1978, pp. 401-405.
2.
Gudbjarnason S., Bing RJ: The index of the lactatepyruvate system in blood as an indicator of the functional state of cellular oxidation. Biochim Biophys Acta, 60:158-162, 1962.
3.
Hlavova A., Linhart J., Prerovsky J., et al: Lactate and pyruvate changes in the leg during and after exercise in normal subjects and in patients with femoral artery occlusion. Clin Sci34:397-409, 1968.
4.
Maas U., Alexander K.: Lactate and pyruvate changes during treadmill exercise in patients with intermittent claudication. Z Kardiol71:39-43, 1982.
5.
Brugmans J., Jaqueneau A., Horig G., et al: Modern technics in venous occlusion plethysmography in the assessment of peripheral vascular disease. Proc Royal Soc70 (Suppl 8):1-6, 1977.
6.
Pointel JP, Gin H., Drouin P., et al: Venous plethysmography measuring techniques and normal values . Angiology32:145-154, 1981.
7.
Borzykowski J., Krähenbühl B.: Measurement of pedal transcutaneous oxygen tension to follow up lower limbs arterial occlusive disease. Vasa10:137-142, 1980.
8.
Elert C., Niebel W., Karuse E., et al:The effect of Naftidrofuryl on energy metabolism in the musculature of limbs with impaired blood flow. Therapie Woche26:3947-3950, 1976.
9.
Archer AG, Robert VC, Watkins PJ: Blood flow patterns in painful diabetic neuropathy. Diabetologia27:563-567, 1984.
10.
Gundersen Hjg : Peripheral blood flow and metabolic control in juvenile diabetes. Diabetologia10:225-231, 1974.
11.
Pointel JP, Stoltz JF, Rousselle D., et al: Peripheral arterial blood flow in insulin dependent diabetic patients. Influence of glycemia control and blood viscosity. In: Hemorheology and Diseases, ed. by Stoltz JF , Drouin P.Nancy , France, Doin1979, pp. 277-284.
12.
Pointel JP, Rousselle D., Ethgen D., et al: Normalisation des débits artériels et des paramètres rhéologiques chez le diabétique sous l'effet de l'équilibre glycémique par pancréas artificiel . In: Hemodynamics of the Limbs 2, ed. by Puel P, Boccalon H, Enjalbert A, Toulouse, France, 1981, pp. 287-291.
