In 30 patients with varying degrees of claudication and 40 normal subjects, plasma levels of β-thromboglobulin were determined. These were significantly higher (p < 0.01) in the patients than in age-matched controls; in the control group the β-thromboglobulin values resulted slightly higher in older subjects. No correlation was found between β-thromboglobulin and the severity of the vascular disease, assessed on the basis of the pain-free interval on the treadmill.
Get full access to this article
View all access options for this article.
References
1.
Moore S., Pepper DS, Cash JD: The isolation and characterization of platelet specific β-globulin (β-thromboglobulin) and the detection of anti-urokinase and anti-plasmin released from thrombin-aggregated washed human platelets. Biochim Biophys Acta379:360-369, 1975.
2.
Rucinski B., et al: Antiheparin proteins secreted by human platelets. Purification, characterization, and radioimmunoassay. Blood53:47-62, 1979.
3.
Kaplan KL, Owen J.: Plasma levels of β-thromboglobulin and platelet factor 4 as indices of platelet activation in vivo. Blood57:199-202, 1981.
4.
Zahavi J., Kakkar VV: β-thromboglobulin—a specific marker of in-vivo platelet release reaction. Thromb Haemostas44:23-29, 1980.
5.
Ludlam CA, et al: The release of a human platelet specific protein measured by radioimmunoassay. Thromb Res6:543-548, 1975.
6.
Ludlam CA: Evidence for the platelet specificity of β-thromboglobulin and studies on its plasma concentration in healthy individuals. Brit J Haematol41:271-278, 1979.
7.
Zahavi J., et al: Enhanced in vivo platelet "release reaction" in old healthy individuals. Thromb Res17:329-336, 1980.
8.
Cella G., et al: β-thromboglobulin, platelet production time and platelet function in vascular disease. Brit J Haematol43:127-136, 1979.
9.
Zahavi J., Zahavi M.: Enhanced platelet release reaction, shortened platelet survival time and increased platelet aggregation and plasma thromboxane B2 in chronic obstructive arterial disease. Thromb Haemostas53:105-109, 1985.