The effects of antiedematous agent with intravenous 10% glycerol on cere bral blood flow (CBF) and metabolism were studied in acute cerebral ischemia experimentally induced by bilateral carotid artery occlusion in spontaneously hypertensive rats (SHR). CBF was measured by the hydrogen clearance tech nique and brain tissue metabolites such as lactate, pyruvate and ATP in the ischemic brain frozen in situ were determined by the enzymatic method.
In comparison with saline-infused SHR, the reduction of CBF in the thala mus following carotid occlusion was significantly small in the glycerol treated SHR. Supratentorial ATP concentration in the 3 hr-ischemic brain was reduced in both groups of rats, but its reduction was significantly smaller in the glycerol- infused group than the other. Lactate and lactate/pyruvate ratio tended to be less increased in the glycerol rats, indicating that ischemic metabolism was re strained by the treatment.
The present results strongly suggest that intravenous glycerol is effective against acute cerebral ischemia from the view point of cerebral hemodynamic and metabolism.
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References
1.
Ng Lky, Nimmannitya J.: Massive cerebral infarction with severe brain swelling: a clinico-pathological study. Stroke1:158-163, 1970.
2.
Katzman R., Clasen R., Klatzo I., et al: Report of joint committee for stroke resources. IV. Brain edema in stroke. Stroke8:512-540, 1977.
3.
Meyer JS, Charney JZ, Rivera VM, et al: Treatment with glycerol of cerebral oedema due to acute cerebral infarction. Lancet2:993-997, 1971.
4.
Mathew NT, Meyer JS, Rivera VM, et al: Double-blind evaluation of glycerol therapy in acute cerebral infarction. Lancet2:1327-1329, 1972 .
5.
Gilsanz V., Rebollar JL, Buencuerpo J., et al: Controlled trial of glycerol versus dexamethasone in the treatment of cerebral oedema in acute cerebral infarction. Lancet1:1049-1051, 1975.
6.
Frithz G., Werner I.: The effect of glycerol infusion in acute cerebral infarction. Acta Med Scand198:287-289, 1975.
7.
Ott EO, Mathew NT, Meyer JS: Redistribution of regional cerebral blood after glycerol infusion in acute cerebral infarction. Neurology24:1117-1126, 1974.
8.
Meyer JS, Shimazu K., Ohuchi T., et al: Cerebral metabolic effects of glycerol infusion in diabetics with stroke. J Neurol Sci21:1-22, 1974.
9.
Meyer JS, Itoh Y., Okamoto S., et al: Circulatory and metabolic effects of glycerol infusion in patients with recent cerebral infarction. Circulation51:701-702, 1975.
10.
Fujishima M. , Sugi T., Morotomi Y., et al: Effects of bilateral carotid artery ligation on brain lactate and pyruvate concentrations in normotensive and spontaneously hypertensive rats. Stroke6:62-66, 1975.
11.
Fujishima M. , Nakatomi Y., Tamaki K., et al: Cerebral ischemia induced by bilateral carotid occlusion in spontaneously hypertensive rats. J Neurol Sci33:1-11, 1977.
12.
Fujishima M. , Ogata J., Sugi T., et al: Mortality and cerebral metabolism after bilateral carotid artery ligation in normotensive and spontaneously hypertensive rats. J Neurol Neurosurg Psychiat39:212-219, 1976.
13.
Nakatomi Y. , Fujishima M., Ishitsuka T., et al: Effects of arterial hypotension on brain metabolism in normotensive and spontaneously hypertensive rats. Stroke12:356-359, 1981.
Gotoh F., Tazaki Y., Fukuuchi Y., et al: Intravenously administered hypertonic glycerol treatment in neurologic diseases. II. Clinical evaluation of 10% (W/V) glycerol, 5% (W/V) fructose saline solution (CG-A30). Jpn JClin Exp Med55;2327-2335, 1978.
16.
Newkirk TA, Tourtellotte WW, Reinglass JL: Prolonged control of increased intracranial pressure with glycerin. Arch Neurol27:95-96, 1972.
17.
Bralet J., Beley P., Bralet A-M., et al: Comparison of the effects of hypertonic glycerol and urea on brain edema, energy metabolism and blood flow following cerebral microembolism in the rat. Deleterious effect of glycerol treatment. Stroke14:597-604, 1983.
18.
Ishitsuka T. , Fujishima M., Sadoshima S., et al: Pulmonary hemorrhage in experimental cerebral ischemia in mongolian gerbils. Brain metabolism and lung pathology . Jpn Heart J25:1073-1080, 1984 .
