Disopyramide Plasma Concentrations Following Single and Multiple Doses of the Immediate- and Controlled-Release Capsules

Abstract

Get full access to this article

View all access options for this article.

References

Bryson SM , Whiting B. , Lawrence JR : Disopyramide serum and pharmacologic effect kinetics applied to the assessment of bioavailability. Br J Clin Pharmacol 6:409, 1978.

Dubetz DK , Brown NN , Hooper WD , et al: Disopyramide pharmacokinetics and bioavailability. Br J Clin Pharmacol 6:279, 1978.

Hinderling PH , Garrett ER : Pharmacokinetics of the antiarrhythmic disopyramide in healthy humans. J Pharmacokin Biopharm 4:199, 1976.

Karim A. : The pharmacokinetics of Norpace. Angiology 26:85, 1975.

Whiting B. , Holford Nhg , Sheiner LB : Quantitative analysis of the disopyramide concentration-effect relationship . Br J Clin Pharmacol 9:67, 1980.

Johnston A. , Henry JA , Warrington SJ , Hamer Naj : Pharmacokinetics of oral disopyramide phosphate in patients with renal impairment . Br J Clin Pharmacol 10:245, 1980.

Shen DD , Cunningham JL , Shudo I. , Azarnoff DL : Disposition kinetics of disopyramide in patients with renal insufficiency . Biopharm Drug Dispos 1: 133, 1980.

Whiting B. , Elliott HL : Disopyramide in renal impairment. Lancet Dec. 24 & 31:1363, 1977.

Ilett KF , Madsen BW , Woods JD : Disopyramide kinetics in patients with acute myocardial infarction. Clin Pharmacol Ther 26:1, 1979.

10.

Oksanen K. , Jounela AJ , Pentikainen PJ : Pharmacokinetics of disopyramide in patients with acute myocardial infarction . Clin Pharmacol Ther 27:276, 1980.

11.

Ward JW , Kinghorn GR : The pharmacokinetics of disopyramide following myocardial infarction with special reference to oral and intravenous dose regimens. J Int Med Res 4(Suppl 1):49, 1976.

12.

Weissberg PL , Matenga J. , Hayler AM , Holt DW : Plasma disopyramide concentrations following a 300-mg oral loading dose in acute myocardial infarction. Ther Drug Monit 4:277, 1982.

13.

Landmark K. , Bredesen JE , Thaulow E. , et al: Pharmacokinetics of disopyramide in patients with imminent to moderate cardiac failure. Eur J Clin Pharmacol 19:187, 1981.

14.

Hulting J. , Jansson B. : Antiarrhythmic and electrocardiographic effects of single oral doses of disopyramide . Eur J Clin Pharmacol 11:91, 1977.

15.

Niarchos AP : Disopyramide: Serum level and arrhythmia conversion . Am Heart J 92:57, 1976.

16.

Rangno RE , Warnica W. , Ogilvie RI , et al: Correlation of disopyramide pharmacokinetics with efficacy in ventricular tachyarrhythmia. J Int Med Res 4 (Suppl 1):54, 1976.

17.

Robert EW , Peters F. , Winkle RA , et al: Pharmacokinetics and clinical efficacy of disopyramide phosphate . Circulation 57 & 58 (Suppl. II):102, 1978.

18.

David BM , Madsen BW , Ilett KF : Plasma binding of disopyramide. Br J Clin Pharmacol 9:614, 1980.

19.

Hinderling PH , Bres J. , Garrett ER : Protein binding and erythrocyte partitioning of disopyramide and its monodealkylated metabolite. J Pharm Sci 63:1684, 1974.

20.

Lima JJ , Boudoulas H. , Blanford M. : Concentration-dependence of disopyramide binding to plasma protein and its influence on kinetics and dynamics. J Pharmacol Exp Ther 219:741, 1981.

21.

McCoy HG , Labrosse KR , Lane JR , et al: Disopyramide plasma protein binding. Drug Intel Clin Pharm 15:481, 1981.

22.

Aitio ML : Plasma concentrations and protein binding of disopyramide and mono-N-dealkyldisopyramide during chronic oral disopyramide therapy. Br J Clin Pharmacol 11:369, 1981.

23.

Cunningham JL , Shen DD , Shudo I. , Azarnoff DL : The effect of non-linear disposition kinetics on the systemic availability of disopyramide. Br J Clin Pharmacol 5:343, 1978.

24.

Cunningham JL , Shen DD , Shudo I. , Azarnoff DL : The effects of urine pH and plasma protein binding on the renal clearance of disopyramide. Clin Pharmacokinet 2:373, 1977.

25.

Giacomini KM , Swezey SE , Turner-Tamiyasu K. , Blaschke TF : The effect of saturable binding to plasma proteins on the pharmacokinetic properties of disopyramide. J Pharmacokin Biopharm 10:1, 1982.

26.

Lima J. : Comparison of free and total disopyramide concentrations following single oral doses. Drug Intel Clin Pharm 15:480, 1981.

27.

Meffin PJ , Robert EW , Winkle RA , et al: Role of concentration-dependent plasma protein binding in disopyramide disposition. J Pharmacokin Biopharm 7:29, 1979.

28.

Sanner JH , Novotney RL , Schulze RH , Kellar PL : Anticholinergic properties of disopyramide phosphate and its mono-N-dealkylated metabolite. Eighth International Congress of Pharmacology, Tokyo, July 19-24, 1981 (Abst. 942), p. 506.

29.

Ankier SI , Kaye CM : The influence of pH on the buccal absorption and renal excretion of disopyramide in man. Br J Clin Pharmacol 3:672, 1976.

30.

Pippenger CE : Therapeutic drug monitoring: An overview. Ther Drug Monit 1:3, 1979.

31.

Meffin PJ , Harapat SR , Harrison DC : Highpressure liquid chromatographic analysis of drugs in biological fluids. III. Analysis of disopyramide and its mono-N-dealkylated metabolite in plasma and urine. J Chromatogr 132:503, 1977.

32.

Metzler CM , Elfring GL , McEwen AJ : A package of computer programs for pharmacokinetic modeling. Biometrics 30:562, 1974.

33.

Sedman AJ , Wagner JG : CSTRIP, a Fortran IV computer program for obtaining initial polyexponential parameter estimates. J Pharm Sci 65:1006, 1976.

34.

Gibaldi M. , Perrier D. : Pharmacokinetics. New York, Marcel Dekker, Inc., 1975.

35.

Wagner JG , Nelson E. : Percent absorbed time plots derived from blood level and/or urinary excretion data. J Pharm Sci 52:610, 1963.

36.

Neter J. , Wasserman W. : Applied linear statistical models. Homewood, Illinois, Richard D. Irwin, Inc., 1974.

37.

Forssell G. , Graffner C. , Nordlander R. , Nyquist O. : Comparative bioavailability of disopyramide after multiple dosing with standard capsules and controlled-release tablets . Eur J Clin Pharmacol 17:209, 1980.

38.

Bechgaard H. , Nielsen GH : Controlled-release multiple-units and single-unit doses. A literature review. Drug Development and Industrial Pharmacy 4:53, 1978.

39.

Aitio ML , Mansury L. , Tala E. , et al: The effect of enzyme induction on the metabolism of disopyramide in man. Br J Clin Pharmacol 11:279, 1981.

40.

Rycroft D. , Daniel JW : The excretion of D-glucaric acid in the urine of human volunteers following the administration of disopyramide. J Int Med Res 4 (Suppl. 1):59, 1976.

41.

Haughey DB , Lima JJ : The influence of blood collection technique on serum and plasma protein binding of disopyramide. Eur J Clin Pharmacol 22:185, 1982.

42.

Cronin M. , Chegwidden K. , Kabakoff D. , et al: Application of an innovative ultrafiltration system for free drug determinations. Clin Pharmacol Ther 29:238, 1981.

43.

Sharps JC , Lima J. , Haughey D. : Effect of alpha-1 acid glycoprotein concentrations and pH on disopyramide protein binding. Drug Intel Clin Pharm 15:484, 1981.