Abstract
The purpose of this paper is to show, by noninvasive measurements, previously undocumented effects on cardiac work of the nitrate coronary vasodilator Pentaerythritol Tetranitrate (Peritrate®). The chew-and-swallow 40-mg tablets of this drug were given to 10 patients of type II AHA classifica tion. The Diastolic Time Tension Index/Systolic Time Tension Index Ratio increased significantly from 1.15 (±0.11 SEM) to 1.46 (±0.13), p<0.05. The Double Product decreased significantly from 9813 (±606) to 8336 (±497), p<0.01. The Triple Product also decreased significantly from 3223 (±235) to 2425 (±206), p<0.01. The percent diastole of the R-R interval increased signifi cantly from 65% (±2.44) to 70% (± 1.73) p<0.05, while no significant change in heart rate occurred (63.2 bts/min to 62.4 bts/min). Correspondingly, there was a decrease of systolic time interval, from 0.33 second (±0.2) to 0.29 second (±.01) p<0.01. A significant decrease in blood pressure was also noted. Sys tolic BP dropped from 155 (±8.0) to 134(±7.2),p<0.01. Diastolic BP dropped from 89.2 (±2.8) to 79.2 (±2.2), p<0.01. This study shows that Peritrate produced significantly favorable changes in all the cited indicators of cardiac work.
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