Platelet Adhesiveness: Methodology for Testing in Humans

Abstract

Platelets play an important role in the pathogenesis of early thrombus formation and might even be involved in initiating the process of atheroscle rosis.

Various platelet adhesiveness test methods are discussed. Results of an in vitro test in about 600 patients with various diseases are given.

The effect from anti-platelet drugs like dipyridamole and acetyl salicylic acid in preventing increase of platelet adhesiveness due to a biologic stressor are compared with those obtained with isoxsuprine.

Platelets play an important role in the pathogenesis of early thrombus formation. Platelets might also be involved in initiating the process of atherosclerosis. Therefore, it is understandable that various test methods to measure platelet behavior has been developed.

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References

Murphy, E.A. , Francis, M.E. : The estimation of blood platelet survival, I. General principles of the study of cell survival. Thromb. Diathes. Haemorrh. (Stuttg.), 22: 281, 1969.

Murphy, E.A. , Francis, M.E. : The estimation of blood platelet survival, II. The multiple hit model. Thromb. Diath. Haemorr., 25: 53, 1971.

Murphy, E.A. : The estimation of blood platelet survival. II. The robustness of the basic models. Thromb. Diath. Haemorr. , 26: 431, 1971.

Murphy, E.A. , Francis, M.E. , Mustard, J.F. : The estimation of blood platelet survival. IV. Characteristics of the residual errors from regression. Thromb. Diath. Haemorrh., 28: 447, 1973.

Bremer, G. , Jacobi, E. , Miller, B. , Ehms, H. , Strohmeyer, G. : Platelet kinetics in Crohns's disease. Klin. Wochenschr., 56: 365, 1978.

Harker, L.A. , Finch, C.A. : Thrombokinetics in man. J. Clin. Invest., 48: 963, 1969.

Jacobi, E. , Hagemann, G. , Poliwoda, H. : Eine In-Vitro Methode zur Bestimmung der Thrombozytenadhäsivität, Thromb. Diath. Haemorrh., 26: 192, 1971.

Jacobi, E. , Kruskemper, G. : Der EinfluB simulierter Sferics (wetterbedingte, elektromagnetische Strahlungen) auf die Thrombozytenadhäsivität. Inn. Med., 2: 73, 1975.

Jacobi, E. , Richter, O. , Kruskemper, G. : Zur Beeinflussung von Thrombozyten-Funktionen. Fortschr. Med., 97: 279, 1979.

10.

Jacobi, E. , Bremer, G. , Richter, O. : Zur Messung der Thrombozytenlebenszeit und ihrer mathematischen Analyse, in Prostaglandine und Plättchenfunktion, edited by Stuttgart, F.K. Schattauer Verlag , H. K. Breddin , 1978.