Effect of Lidoflazine on Systemic Arteries and Veins

Bernstein, V. , Peretz, D.I. : Lidoflazine, a new drug in the treatment of angina pectoris. Curr. Ther. Res., 14: 483-495, 1972.

Piessens, J. , De Geest, H. : Long-term evaluation of lidoflazine in angina pectoris based on exercise tolerance. Cardiology, 57: 135-149, 1972.

Nordstrom, L.A. , Gobel, F.L. : The effect of lidoflazine on exercise tolerance in patients with angina pectoris. Chest, 74: 50-54, 1978.

Jenkins, M.D. , Swallow, E.A. , Kidner, P.H. : A double blind placebo controlled trial of lidoflazine in angina pectoris. Br. Heart J., in press, 1979.

Gobel, F.L. , Nordstrom, L.A. , Nelson, R.R. , et al.: Effect of lidoflazine on myocardial performance and myocardial blood flow in patients with angina pectoris. Second International Lidoflazine Symposium, Hamburg (Germany), May 9-10, 1975.

Schaper, W.K.A. , Xhonneux, R. , Jageneau, A.H.M. , et al.: The cardiovascular pharmacology of lidoflazine, a long-acting coronary vasodilator. J. Pharmacol. Exp. Ther., 152: 265-274, 1966.

Thomsen, J.H. , Stenlund, R.R. , Corliss, R.J. , et al.: The systemic and coronary hemodynamic effects of lidoflazine. Arch. Int. Pharmacodyn., 172: 15-23, 1968.

Marshall, R.J. , Parratt, J.R. : Drug-induced changes in blood flow in the acutely ischaemic canine myocardium: Relationship to subendocardial driving pressure. Clin. Exp. Pharmacol. Physiol., 1: 99-112, 1974.

De Cock, W. , Schuermans, V. , Jagenau, A. , et al.: Resting, exercise and postexercise heart rate and systolic time intervals in normal men treated with lidoflazine. Arzneim. Forsch. (Drug Res.), 23: 1450-1454, 1973 .

Detry, J.-M.R. , Rousseau, M.F. , Filleul, P. , et al.: Hemodynamic effects of lidoflazine during graded levels of bicycle exercise in normal subjects. Eur. J. Cardiol., 4: 165-174, 1976.

Shepherd, J.T. , Vanhoutte, P.M. : Veins and Their Control. Philadelphia, W. B. Saunders, 1975 , pp. 1-269.

Shepherd, J.T. , Vanhoutte, P.M. : The Human Cardiovascular System. Facts and Concepts. New York, Raven Press , 1979 pp. 1-351.

Vanhoutte, P. , Clement, D. , Leusen, I. : The reactivity of isolated veins to electrical stimulation. Arch. Int. Physiol. Biochem., 75: 641-657, 1967.

Vanhoutte, P. , Leusen, I. : The reactivity of isolated venous preparations to electric stimulation. Pflügers Arch., 306: 341-353, 1969.

De Mey, J. , Vanhoutte, P.M. : Comparison of the responsiveness of cutaneous veins of dog and rabbit to adrenergic and cholinergic stimulation. Blood Vessels, in press (1980).

Verbeuren, T.J. , Janssens, W.J. , Vanhoutte, P.M. : Effects of moderate acidosis on adrenergic neurotransmission in canine saphenous veins. J. Pharmacol. Exp. Ther., 206: 105-114, 1978.

Verbeuren, T.J. , Coen, E. , Vanhoutte, P.M. : Determination of 3H-norepinephrine and its metabolites in superfusate from isolated blood vessels. Arch. Int. Pharmacodyn., 227: 171-174, 1977.

Muldoon, S.M. , Vanhoutte, P.M. , Tyce, G.M. : Norepinephrine metabolism in canine saphenous vein: Prevalence of glycol metabolites. Am. J. Physiol., 234: H235-H243, 1978.

Muldoon, S.M. , Janssens, W.J. , Verbeuren, T.J. , et al.: Alpha-adrenergic blocking properties of droperidol on isolated blood vessels of the dog. Br. J. Anaesthesia, 49: 211-216, 1977.

Türker, R.K. , Kayaalp, S.O. : Effect of lidoflazine on norepinephrine, angiotensin and serotonin responses in isolated smooth muscle preparations . Experientia, 28: 647, 1967.

Godfraind, T. , Polster, P. : Etude comparative de médicaments inhibitant la réponse contractile de vaisseaux isolés d'origine humaine ou animale. Thérapie, 23: 1209-1220, 1968.

Van Nueten, J.M. , Wellens, D. : Tissue specificity of calcium-antagonistic properties of lidoflazine. Arch. Int. Pharmacodyn., in press 1980.

Lorenz, R.R. , Vanhoutte, P.M. : Inhibition of adrenergic neurotransmission in isolated veins of the dog by potassium ions. J. Physiol. , 246: 479-500, 1975.

Vanhoutte, P.M. , Verbeuren, T.J. : Inhibition by acetylcholine of the norepinephrine release evoked by potassium in canine saphenous vein. Circ. Res., 39: 263-269, 1976.

Van Nueten, J.M. : Comparative bioassay of vasoactive drugs using isolated perfused rabbit arteries. Eur. J. Pharmacol. , 6: 286-293, 1969.

Godfraind, T. , Kaba, A. : Blockade or reversal of the contraction induced by calcium and adrenaline in depolarized arterial smooth muscle. Br. J. Pharmacol., 36: 549-560, 1969.

Kosche, F. , Raff, K.W. , Lochner, W. : Influence of the extracellular calcium concentration on the action of coronary dilators (a contribution to the mechanism of the action of coronary dilators). Plfügers Arch. Physiol., 335: 46-57, 1972.

Van Nueten, J.M. , Van Beek, J. , Vanhoutte, P.M. : Inhibitory effect of lidoflazine on contractions of isolated canine coronary arteries caused by norepinephrine, 5-hydroxytryptamine, high potassium, anoxia and ergonovine maleate. J. Pharmacol. Exp. Ther., accepted for publication. Van Nueten, J.M. , Wellens, D. : Mechanisms of vasodilatation and antivasoconstriction. Angiology, 30: 440-446, 1979.

Van Nueten, J.M. : Vasodilatation or inhibition of peripheral vasoconstriction? in Mechanisms of Vasodilatation. Edited by P. M. Vanhoutte , I. Leusen. Basel, S. Karger, 1978, pp. 137-143.

Van Belle, H. : The disappearance of adenosine in dog blood after low oral doses of lidoflazine (0.31-5 mg/kg). Eur. J. Pharmacol., 10: 290-292, 1970.

Van Belle, H. : The disappearance of adenosine in blood. Effect of lidoflazine and other drugs. Eur. J. Pharmacol. , 11: 241-248, 1970.

Afonso, S. , O'Brien, G.S. : Mechanism of enhancement of adenosine action by dipyridamole and lidoflazine in dogs. Arch. Int. Pharmacodyn., 194: 181-196, 1971.

Spieckerman, P.G. , Fuchs, C. , Gethmann, J.W. , et al.: Einfluss des Koronardilatators Lidoflazin auf den Adenosinstoffwechsel des Myokards während Ischämie und Anoxie. Arzneim. Forsch., 22: 1869-1874, 1972.

De Clerck, F.F. , Reneman, R.S. : Effect of lidoflazine (R 7904) on uptake and release of serotonin by human platelets in vitro.

Janssens, W.J. , Vanhoutte P.M. : Instantaneous changes of alpha-adrenoceptor affinity caused by moderate cooling in canine cutaneous veins. Am. J. Physiol., 234: H330-H337, 1978.

Vanhoutte, P.M. : Effect of anoxia and glucose depletion on isolated veins of the dog. Am. J. Physiol., 230: 1261-1268, 1976.

Vanhoutte, P.M. : Heterogeneity of vascular smooth muscle, in Microcirculation. Edited by G. Kaley , B. M. Altura. Baltimore, University Park Press, 1978, pp. 181-309.

Vanhoutte, P.M. : Adrenergic neuroeffector interaction in the blood vessel wall. Fed. Proc., 37: 181-186, 1978.

Haeusler, G. : The effect of verapamil on the contractility of smooth muscle and on excitation-secretion coupling in adrenergic nerve terminals. Angiologica, 8: 156-160, 1971.

Afonso, S. , O'Brien, G.S. , Crumpton, W. : Enhancement of coronary vasodilating action of ATP and adenosine by lidoflazine . Circ. Res., 22: 43-48, 1968.

Jageneau, A.H.M. , Schaper, W.K.A. , Van Gerven , W. : Enhancement of coronary reactive hyperemia in unanaesthetized pigs by an adenosine-potentiator (lidoflazine) . Arch. Pharmacol., 265: 16-23, 1969.