Prazosin was administered orally at a maximal dose of 2 mg every 6 hours to 4 patients with congestive heart failure (CHF) who had not received either digitalis or diuretics for 72 hours before therapy. Three of the 4 patients had hypertensive and arteriosclerotic heart disease. Hemodynamic monitoring in dicated a significant reduction of preload and afterload with a concomitant rise in the cardiac index. We concluded that isolated low-dose oral prazosin has salutary effects on indices of hemodynamic function in selected patients.
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References
1.
Miller, R.R. , Awan, N.A., Maxwell, K.S., et al.: Sustained reduction of cardiac impedance and preload in congestive heart failure with the antihypertensive vasodilator prazosin. N. Engl. J. Med., 297: 303-307, 1977.
2.
Elkayam, U., Rotmensch, H.H., Terdiman, R., et al.: Hemodynamic effects of chlorpromazine in patients with acute myocardial infarction and pump failure. Chest, 72: 623-627, 1977.
3.
Awan, N.A., Miller, R.R., DeMaria, A.N., et al.: Efficacy of ambulatory systemic vasodilator therapy with oral prazosin in chronic refractory heart failure. Concomitant relief of pulmonary congestion and elevation of pump output demonstrated by improvements in symptomatology, exercise tolerance, hemodynamics and echocardiography. Circulation , 56: 346-354, 1977.
4.
Aronow, W.S. , Greenfield, R.S., Alimadadian, H., et al.: Effect of the vasodilator trimazosin versus placebo on exercise performance in chronic left ventricular failure . Am. J. Cardiol., 40: 789-793, 1977.
5.
Miller, R.R. , Awan, N.A., Joye, J.A., et al.: Combined dopamine and nitroprusside therapy in congestive heart failure. Greater augmentation of cardiac performance by addition of inotropic stimulation to afterload reduction. Circulation, 55: 881-884, 1977.
6.
Braunwald, E., Ross, J., Jr., Sonnenblick, E.H. : Mechanisms of Contraction of the Normal and Failing Heart. Second edition. Boston, Little Brown and Company, 1976.
7.
Franciosa, J.A. , Limas, C.J., Guiha, N.H., et al.: Improved left ventricular function during nitroprusside infusion in acute myocardial infarction. Lancet, March 25, 1972, 650-654.
8.
Chatterjee, K., Parmley, W.W., Ganz, W., et al.: Hemodynamic and metabolic responses to vasodilator therapy in acute myocardial infarction. Circulation , 68: 1183-1193, 1973.
9.
Mikulic, E., Cohn, J.N., Franciosa, J.A.: Comparative hemodynamic effects of inotropic and vasodilator drugs in severe heart failure. Circulation, 56: 528-533, 1977.
10.
Chatterjee, K., Parmley, W.W., Swan, H.J.C., et al.: Beneficial effects of vasodilator agents in severe mitral regurgitation due to dysfunction of subvalvular apparatus . Circulation, 68: 684-690, 1973.
11.
Massie, B., Chatterjee, K., Werner, J., et al.: Hemodynamic advantage of combined administration of hydralazine orally and nitrates nonparenterally in the vasodilator therapy of chronic heart failure. Am. J. Cardiol., 40: 794-801, 1977.
12.
Goth, A.: Medical Pharmacology. Principles and Concepts. Eighth edition. St. Louis, C.V. Mosby Company, 1976 , pp 165-166.
