Theoretical and Practical Aspects of Thrombolytic Therapy

Hirsh, J. , O'Sullivan, E.F. , and Martin, M. : Evaluation of a standard dosage schedule with streptokinase. Blood, 35: 341, 1970.

Fletcher, A.P. , Alkjaersig, N. , Sherry, S. , Genton, E. , Hirsh, J. , and Bachman, F. : The development of urokinase as a thrombolytic agent: Maintenance of a sustained thromboembolic state in man by its intravenous infusion. J. Lab. Clin. Med., 65: 713, 1965.

Sherry, S. : Fibrinolysis. Ann. Rev. Med. 19: 247, 1968.

Bruner-Lorand, J. , and Pilkington , R.E. : Inhibitors of fibrin cross-linking: Relevance for thrombolysis. Nature, 210: 1273, 1966.

Henderson, K.W. , and Nussbaum, M. : The mechanism of enhanced streptokinase-induced clot lysis following in-vitro Factor XIII inactivation. Br. J. Haematol., 17: 445, 1969.

Feddersen, C. , and Gormsen, J. : Plasma digestion of stabilized and non-stabilized fibrin illustrated by pH-stat titration and thromboelastography. Scand. J. Clin. Lab. Invest., 27: 175, 1971.

Alkjaersig, N. , Fletcher, A.P. , and Sherry, S. : The mechanism of clot dissolution by plasmin . J. Clin. Invest., 38: 1086, 1959.

Hedner, V. , Nilsson, I.M. , and Robertson, B. : Determination of plasminogen in clots and thrombi. Thromb. Diath. Haemorrh., 16: 38, 1966.

Chesterman, C.N. , Allington, M.J. , and Sharp, A.A. : Relationship of plasminogen activator to fibrin. Nature, 238: 15, 1972.

Amery, A. , Donati, M.B. , Vermylen, J. , and Verstraete, M. : Comparison between the changes in the plasma fibrinogen and plasminogen levels induced by a moderate or high initial dose of streptokinase. Thromb. Diath. Haemorrh., 23: 504, 1970.

Ambrus, C.M. , and Markus, G. : Plasmin-Antiplasmin complex as a reservoir of fibrinolytic enzymes. Am. J. Physiol. 199: 491, 1960.

Harpel, P.C. , and Mosesson, M.W. : Degradation of human fibrinogen by plasma α2 macroglobulin-enzyme complexes. J. Clin. Invest., 52:

Jørgensen, L. , Rowsell, H.C. , Hovig, T. , and Mustard, J.F. : Resolution and organization of platelet-rich mural thrombi in carotid arteries of swine. Am. J. Pathol. , 51: 681, 1967.

Hirsh, J. , Buchanan, M. , Glynn, M.F. , and Mustard, J.F. : Effect of activation of the fibrinolytic mechanism on experimental platelet-rich thrombi. J. Lab. Clin. Med., 72: 245, 1968.

Fletcher, A.P. , Alkjaersig, N. , and Sherry, S. : The maintenance of a sustained thrombolytic state in man. I. Induction and effects. J. Clin. Invest., 38: 1096, 1959.

Fletcher, A.P. , Alkjaersig, N. , and Sherry, S. : The clearance of heterologous protein from the circulation of normal and immunized man. J. Clin. Invest. , 37: 1306, 1958.

Verstraete, M. , Vermylen, M. , Amery, A. , and Vermylen, C. : Thrombolytic therapy with streptokinase using a standard dosage scheme. Br. Med. J., 1: 454, 1966.

Fletcher, A.P. , Alkjaersig, M. , and Sherry, S. : Fibrinolytic mechanisms and the development of thrombolytic therapy. Am. J. Med., 33: 738, 1962.

Hirsh, J. , Hale, G. , MacDonald, I. , McCarthy, R. , and Pitt, A. : Streptokinase therapy in acute major pulmonary embolism: Effectiveness and problems. Br. Med. J., 21: 729, 1968.

Hirsh, J. , McDonald, I. , and O' Sullivan, E. : Comparison of the effects of streptokinase and heparin on the early rate of resolution of major pulmonary embolism. Can. Med. Assoc. J. , 104: 488 & 516, 1971.

Miller, G. , Sutton, G. , Kerr, I. , Gibson, R. , and Honey, M. : Comparison of streptokinase and heparin in treatment of isolated acute massive pulmonary embolism. Br. Med. J., 2: 681, 1971.

The urokinase pulmonary embolism Trial: Circulation (Suppl. II), 47 & 48: 1, 1973.

Tow, D. , Wagner, H. , Jr., and Holmes, R. : Urokinase in pulmonary embolism. N. Engl. J. Med., 277:1161, 1967.

Donald, G.A. , Williams, G. , Scannell, J.G. , and Shaw, R.S. : A reappraisal of the application of the Trendelenburg operation to massive fetal pulmonary embolism. N. Engl. J. Med., 268: 171, 1963.

Chait, A. , Summers, D. , Krasinow, N. , and Wechsler, B.M. : Observations on the fate of large pulmonary emboli. Am. J. Roentgenol., 100: 364, 1967.

Kakkar, V. , Flanc, C. , Howe, C. , O'Shea, M. , and Flute, P. : Treatment of deep vein thrombosis: A trial of heparin, streptokinase and Arvin . Br. Med. J., 1: 806, 1969.

Kakkar, V. , Flanc, C. , O'Shea, M. , Flute, P. , Howe, C. , and Clarke, M. : Treatment of deep vein thrombosis with streptokinase. Br. J. Surg., 56: 178, 1969.

Schmutzler, R. , and Koller, F. : Thrombolytic therapy. In: Poller, L. (ed.), Recent Advances in Blood Coagulation, p. 299. Little, Brown, Boston, 1969.

Salmon, J. : Fibrinolyse et Pathologie Vasculaire, p. 207. Arscia, S. , Bruxelles and Maloine, S. (eds.), Paris, 1964.

Verstraete, M. , Amery, A. , and Vermylen, J. : Feasibility of adequate thrombolytic therapy with streptokinase and peripheral arterial occlusions. I. Clinical and arteriographic results. Br. Med. J., 1: 1499, 1963.

Verstraete, M. , Vermylen, J. , and Donati, M. : The effect of streptokinase infusion on chronic arterial occlusions and stenoses. Ann. Intern. Med., 74: 377, 1971.

Hirsh, J. , O'Sullivan, E.F. , Gallus, A.S. , and Gilford, E.J. : Arterial thrombosis in a patient with chronic thrombocytopenia: Successful treatment with intra-arterial infusion of streptokinase. Med. J. Aust., 2: 1304, 1969.

Gallus, A.S. , and Hirsh, J. : Combined use of low dose streptokinase and full dose heparin. Proceedings of the Fifteenth Congress of the International Society of Hematology, Jerusalem, (In press) 1974.

Sherry, S. : Streptokinase therapy for thromboembolic vascular occlusive vascular disease . Ann. Intern. Med., 74: 437, 1971.