Labile (Borderline) Hypertension—New Aspects of a Common Disorder

Pickering, G. : Hypertension. Definitions, natural histories and consequences. Amer. J. Med., 52: 570, 1972.

Stamler, J. , Schonberger, J.A. , Shekelle, R.B. and Stamler, R. : Hypertension, the problem and the challenge. In the Hypertension Handbook, p. 3. Merck. Sharp & Dohme, West Point, 1974.

Julius, S. and Schork, M.A. : Borderline Hypertension—A critical review. J. Chron. Dis., 23: 723, 1971.

Evelyn, K.A. : A long-term study of the natural history of essential hypertension. Ann. Int. Med., 33: 629, 1950.

Widimsky, J. , Fejfarova, M.H. and Fejfar, Z. : Changes of cardiac output in hypertensive disease. Cardiologia (Basel), 31: 381, 1957.

Eich, R.H. , Cuddy, R.P. , Smulyan, H. and Lyons, R.H. : Hemodynamics in labile hypertension: a follow-up study. Circulation , 34: 299, 1966.

Sannerstedt, R. , Julius, S. and Conway, J. : Hemodynamic responses to tilt and beta-adrenergic blockade in young patients with borderline hypertension. Circulation, 42: 1057, 1970.

Frohlich, E.D. , Kozul, V.J. , Tarazi, R.C. and Dustan, H.P. : Physiological comparison of labile and essential hypertension. Circul. Res., 26-27/I: 55, 1970.

Frohlich, E.D. , Dustan, H.P. and Page, I.H. : Hyperdynamic beta-adrenergic circulatory state. Arch. Intern. Med., 117: 614, 1966.

Julius, S. , Pascual, A.V. and London, R. : Role of parasympathetic inhibition in the hyperkinetic type of borderline hypertension. Circulation, 44: 413, 1971.

Gordon, R.D. , Kuchel, O. , Liddle, G.W. and Island, D.P. : Role of the sympathetic nervous system in regulating renin and aldosterone production in man. J. Clin. Invest., 46: 599, 1967.

Winer, N. , Chokshi, D.S. , Yoon, M.S. and Freedman, A.D. : Adrenergic receptor mediation of renin secretion. J. Clin. Endocr., 29: 1168, 1969.

Ganong, W.F. : Effects of sympathetic activity and ACTH on renin and aldosterone secretion . In: Hypertension '72, p. 4. editors J. Genest and Koiw, E. Springer-Verlag, Berlin, Heidelberg , New York, 1972.

Robison, G.A. , Butcher, R.W. and Sutherland , E.W. : Adenyl cyclase as an adrenergic receptor. Ann. N. Y. Acad. Sci., 139: 703, 1967.

Michelakis, A.M. , Caudle, J. and Liddle, G.W. : In vitro stimulation of renin production by epinephrine, norepinephrine and cyclic AMP. Proc. Soc. Exp. Biol. (N.Y.), 130: 748. 1969.

Winer, N. , Chokshi, D.S. and Walkenhorst, W.G. : Effects of cyclic AMP, sympathomimetic amines and adrenergic receptor antagonists on reoin secretion. Circulat. Res., 29: 239, 1871.

Kuchel, O. , Hamet, P. , Tolis, G. , Fraysse, J. , Trachewsky, D. and Genest, J. : Adenosine 3':5'-cyclic monophosphate in human hypertension. "The Nervous System in Arterial Hypertension", S. Julius and M. Esler , editors. C. C Thomas. Springfield, III. 1975.

Cuche, J.L. , Kuchel, O. , Barbeau, A. , Langlois, Y. , Boucher, R. , Genest, J. : Autonomic nervous system and benign essential hypertension in man. I. Usual blood pressure, catecholamines, renin and their interrelationships. Circulation Research, 35: 281, 1974.

Von Euler, U.S. , Hellner, S. and Purkhold, A. : Excretion of noradrenaline in urine in hypertension . Scand. J. Clin. Lab. Invest., 6: 54, 1954.

Serrano, P.A. , Figueroa, G. , Torres, M. and Del Angel, A.R. : Adrenaline, noradrenaline and dopamine excretion in patients with essential hypertension. Amer. J. Cardiol., 13: 484, 1964.

Moller, P. , Buus, O. and Bierring, E. : Blood pressure and urinary excretion of nor-adrenaline. (NA) Scand. J. Clin. Lab. Invest., 9: 331, 1957.

Brunjes, S. : Catecholamine metabolism in essential hypertension . New Engl. J. Med., 271: 20, 1964.

Goodall, McC. and Bogdonoff, M. : Essential hypertension with an elevated noradrenaline excretion. Amer. Heart J., 61: 640, 1961.

DeQuattro, V. and Sjoerdsma, A. : Catecholamine turnover in normotensive and hypertensive man: effects of antiadrenergic drugs. J. Clin. Invest., 47: 2359, 1968.

Sourkes, T.L. , and Murphy, G.F. : Determination of catecholamines and catecholamino acids by differential spectrophotofluorimetry. Meth. med. Res., 9: 147, 1961.

Sato, T.L. : The quantitative determination of 3-methoxy-4-hydroxyphenylacetic acid (homovanillic acid) in urine. J. Lab. Clin. Med., 66: 517, 1965.

Anton, A.H. and Sayre, D.F. : A study of the factors affecting the aluminum oxide trihydroxyindole procedure for the analysis of catecholamines. J. Pharmacol. Exp. Ther., 138: 360, 1962.

Boucher, R. , Veyrat, R. , DeChamplain, J. and Genest, J. : New procedure for measurements of human plasma angiotensin and renin activity levels. Canad. Med. Ass. J. , 90: 194, 1964.

Cuche, J.L. , Kuchel, O. , Barbeau, A. and Genest, J. : Urinary excretion of homovanillic acid in benign essential hypertension, a biochemical marker of labile hypertension . Canad. Med. Ass. J. accepted for publication 1975.

Cuche, J.L. , Kuchel, O. , Barbeau, A. , Hamet, P. , Boucher, R. and Genest, J. : Système nerveux adrénergique et hypertension artérielle essentielle. Union Méd. Canada, 102: 812, 1973.

Louis, W.J. , Doyle, A.E. and Anaveka, S. : Plasma norepinephrine levels in essential hypertension. New Engl. J. Med., 288: 599, 1973 .

Guyton, A.C. , Coleman, T.G. , Cowley, A.W. , Scheel, K.W. , Manning, R.D. Jr., and Norman , R.A. Jr.: Arterial pressure regulation. Overriding dominance of the kidneys in longterm regulation and in hypertension. Amer. J. Med., 52: 584, 1972.

Kuchel, O. , Cuche, J.L. , Hamet, P. , Barbeau, A. , Boucher, R. and Genest, J. : Catecholamines, cyclic adenosine monophosphate and renin in labile hypertension . In: Mechanisms of hypertension, p. 160. M. P. Sambhi , editor. Amsterdam, Excerpta Medica, 1973.

Kuchel, O. , Cuche, J.L. , Hamet, P. , Boucher, R. , Barbeau, A. and Genest, J. : The relationship between adrenergic nervous system and renin in labile hyperkinetic hypertension. In: "Hypertension '72", p. 118. J. Genest and E. Koiw , editors. Springer-Verlag, Berlin, Heidelberg, New York, 1972.

Esler, M.D. and Nestel, P.J. : Sympathetic responsiveness to head-up tilt in essential hypertension. Clin. Sci., 44: 213, 1973.

Frohlich, E.D. , Tarazi, R.C. , Ulrych, M. , Dustan, H.P. and Page, I.H. : Tilt test for investigating a neural component in hypertension: its correlation with clinical characteristics. Circulation, 36: 387, 1967.

Braunwald, E. : Regulation of the circulation, New Engl. J. Med., 290: 1124, 1974.

Safar, M.E. , Weiss, Y.A. , Levenson, J.A. , London, G.M. , Milliez, P.L. : Hemodynamic study of 85 patients with borderline hypertension. Amer. J. Cardiol., 31: 315, 1973.

Ellis, C.N. and Julius, S. : Role of central blood volume in hyperkinetic borderline hypertension. Brit. Heart J., 35: 450, 1973.

Dairman, W. , Gordon, R. , Spector, S. , Sjoerdsma, A. , and Udenfriend, S. : Increased synthesis of catecholamines in the intact rat following administration of α-adrenergic blocking agents. Mol. Pharmacol., 4: 457, 1968.

Robison, G.A. , Butcher, R.W. and Sutherland , E.W. : Cyclic AMP. New York and London, Academic Press, 1971.

Hamet, P. , Kuchel, O. and Genest. J. : Effect of upright posture and isoproterenol infusion on cyclic adenosine monophosphate excretion in control subjects and patients with labile hypertension. J. Clin. Endocr. Metab., 36: 218, 1973.

Hamet, P. , Kuchel, O. , Fraysse, J. and Genest, J. : Plasma adenosine 3':5'-cyclic monophosphate in human hypertension. Canad. Med. Ass. J., 111: 323, 1974.

Hamet, P. , Kuchel, O. , Cuche, J.L. , Boucher, R. and Genest, J. : Effect of propranolol on cyclic AMP excretion and plasma renin activity in labile essential hypertension. Canad. Med. Ass. J., 109: 1099, 1973.

Messerli, F.H. , Kuchel, O. , Tolis, G. , Hamet, P. , Fraysse, J. and Genest. J. : Clin. Res. 23: 1975 (abstract) to be published.

DeQuattro, V. and Miura, Y. : Neurogenic factors in human hypertension: mechanism or myth? Amer. J. Med., 55: 362, 1973.

Charvat, J. , Dell, P. and Folkow, B. : Mental factors and cardiovascular diseases . Cardiologia, 44: 124, 1964.

DeQuattro, V. : Evaluation of increased norepinephrine excretion in hypertension using L-Dopa-3H. Circ. Res., 28: 84, 1971.

Gitlow, S.E. , Mendlowitz, M. , Wilk, E.K. , Wilk, S. , Wolf, R.L. and Naftchi, N.E. : Plasma clearance of dl-β-3H norepinephrine in normal human subjects and patients with essential hypertension. J. Clin. Invest., 43: 2009, 1964.

Engelman, K. , Portnoy, B. : A sensitive double isotope derivative assay for norepinephrine and epinephrine: normal resting human plasma levels. Circ. Res., 26: 53, 1970.

Christensen, N.J. : Increased levels of plasma noradrenaline in hypothyroidism. J. Clin. Endocr., 35: 359, 1972.

Karlberg, B.E. , Henriksson, K.G. , Andersson, R.G.G. : Cyclic adenosine 3',5'-monophosphate concentration in plasma, adipose tissue and skeletal muscle in normal subjects and in patients with hyper- and hypothyroidism. J. Clin. End. Metab., 39: 96, 1974.

Hartrodt, W. , Brosowski, K.H. , Kreher, C. , Graff, Ch. , Ziprian, H. and Baumann, R. : Die Plasmarenin-Aktivitat bei exogener Belastung von essentiellen Hypertonikern und Normotonikern. Acta Biol. Med. Germ., 26: 1013, 1971.

Galdwell, J.R. and Carretero, O.A. : Plasma renin and blood pressure after sympathetic stimulation in normotensive and hypertensive patients. Amer. J. Cardiol., 29: 466, 1972.

Nowaczynski, W. , Kuchel, O. , Genest, J. , Messerli, F.H. , Honda, M. , Tolis, G. , Parvin-Pande, R. , Kubo, S. , Grose, J. and Lebel, M. : Dynamic aldosterone and 18-hydroxydeoxycorticosterone studies in labile and stable benign essential hypertension. Presented at the fourth Intern. Congr. on Hormonal Steroids, 2-7 September 1974 , Mexico, Mexico. To be published in J. Ster. Biochem.