Dosage of IV Brinase in Man Based On Brinase Inhibitor Capacity and Coagulation Studies

Bergkvist, R. , and Svärd. P.O. : Studies on the thrombolytic activity of a protease from Aspergillus oryzae. Acta physiol. scand., 60: 363, 1964.

Bergström, K. , Blombäck, B. , and Kleen, G. : Studies on the plasma fibrinolytic activity in a case of liver cirrhosis. Acta med. scand., 168: 291, 1960.

Blombäck, M. , Blombäck, B. , Olsson , P.I. , and Svendsen , L. : Assay of thrombin-like enzymes and its inhibitors with a synthetic peptide substrate. VI Int. Congr . Thrombosis and Haemostasis, Vienna 1973.

Ekeström, S. , Frisch, E.P. , Lund, F. , and Magaard, F. : Brinase treatment of advanced peripheral arterial disease. 1975. To be published.

Fagerhol, M.K. , and Abildgaard, U. : Immunological studies on human antithrombin III. Influence of age, sex and use of oral contraceptives on serum-concentration . Scand. J. Haemat., 7: 10, 1970.

Freedman, H.J. , and Roschlau, W.H.E. : Some factors influencing the toxicity of thrombolytic enzvmes (brinase). Canad. J. Phvsiol. Pharmacol. , 48: 69, 1970.

Frisch, E.P. , and Kiessling, H. : Dosage of iv brinase based on determination of brinase inhibitor capacity. 1975. To be published.

Godal, H.C. , and Abildgaard, U. : Gelation of soluble fibrin in plasma by ethanol. Scand. J. Haemat., 3: 342, 1966.

Jürgens, J. , Lindvall, S. , Magnusson, O. , and Orth, K. : Inhibitors in plasma from man treated with a protease from Asperigillus oryzae . Acta physiol. scand., 78: 11, 1970.

Kiessling, H. : Determination of brinase inhibitors in plasma in plasma by use of azocollagen as a substrate. 1974. To be published.

Kiessling, H. , and Frisch, E.P. : Activity and immunological reactivity of brinase inhibitors in human plasma . 1975. To be published.

Kiessling, H. , and Svensson, R. : Influence of an enzyme from Aspergillus oryzae, Protease I. on some components of the fibrinolytic system. Acta chem. scand., 24: 569, 1970.

Lund, F. , Ekeström, S. , Frisch, E.P. , and Magaard, F. : Thrombolytic treatment with brinase of advanced arterial obliterative disease of the limbs. Angiology (Balt), 26: 534, 1975.

Mancini, G. , Carbonara, A.O. , and Heremans , J.F. : Immunochemical quantitation of antigens by single radial immunodiffusion. Int. J. Immunochem ., 2: 235, 1965.

Merskey. C. , Kleiner, G.J. , and Johnson, A.J. : Quantitative estimation of split products of fibrinogen in human serum, relation to diagnosis and treatment. Blood. 28: 1, 1966.

Nilsson, I.M. , Blomback, M. , and von Francken , I. : On an inherited autosomal hemorrhagic diathesis with antihemophilic globulin (AHG) deficiency and prolonged bleeding time. Acta med. scand., 159: 35, 1957.

Noren, I. : Specific assay of prothrombin. A method using a freeze-dried reagent of intrinsic coagulation factors. Scand. J. clin. Lab. Invest. , 25: 47, 1970.

Nyman, D. : Aktiverad partiell tromboplastintid vid diagnostik av koagulationsrubbningar. (Actived partial thromboplastin time in diagnosing coagulation disturbances.) Lakartidningen, 70: 3241, 1973.

Owren, P.A. : Thrombotest. A new method for controlling anticoagulant therapy. Lancet, 2: 754, 1959.

Owren, P.A. , and Strandli, O.K. : Normotest. Farmacoter. , I-II: 14, 1969

Roschlau, W.H.E. : Thrombolytic properties and side effects of brinase (fibrinolytic enzyme from Aspergillus oryzae) in the dog. J. clin. Path., 25: 635, 1972

Vermylen, C. , de Vreker, R.A. , and Verstraete , M. : A rapid enzymatic method for assay of fibrinogen fibrin polymerization time (FPT-test) . Clin. chim. Acta, 8: 418, 1963.

Wolf, P. : A modification for routine laboratory use of Stefanini's method of estimating factor V activity in human oxalated plasma. J. clin. Path. , 6: 34, 1953.