Neurohumoral Mechanisms in Hypertension

Manger, W.M. , Wakim, K.D. and Bollman, J.L. : Chemical Quantitation of Epinephrine and Norepinephrine in Plasma . Springfield, Charles C Thomas , 1959 .

Wolf, R.L. , Mendlowitz, M. , Roboz, J. and Gitlow, S.E. : Simultaneous urinary assays for the combined metanephrines and 3-methoxy-4-hydroxyphenylglycol in patients with pheochromocytoma and primary hypertension. N. Engl. J. Med. 203: 1459, 1965.

Gitlow, S.E. , Khassis, S. , Cohen, G. , Mendlowitz, M. and Sha, J. : Diagnosis of pheochromocytoma by determination of urinary 3-methoxy, 4-hydroxymandelic acid. J. Clin. Invest. 39: 221, 1960.

Gitlow, S.E. , Mendlowitz, M. and Bertani, L.M. : The biochemical techniques for detecting and establishing the presence of a pheochromocytoma. Am. J. Cardiol. 26: 270, 1970.

Sjoerdsma, A. , Leeper, L.C. , Terry , L.L. and Udenfriend , S. : Studies on biogenesis and metabolism of norepinephrine in patients with pheochromocytoma . J. Clin. Invest. 38: 31, 1959.

Wolf, R.L. , Mendlowitz, M. , Roboz, J. , Naftchi, N.E. and Gitlow, S.E. : Urinary normetanephrine and metanephrine excretion, separately assayed in normotensive, hypertensive and pheochromocytoma patients. J. Clin. Invest. 45: 1088, 1966.

Von Euler, U.S. : Noradrenaline. Springfield, Charles C Thomas, 1956.

Engelman, K. : Principles in the diagnosis of pheochromocytoma. Bull. N.Y. Acad. Med. 45: 851, 1969.

Roth, G.M. , Flock, E.V. , Kvale, W.F. , Waugh, J.M. and Ogg, J. : Pharmacologic and chemical tests as an aid in the diagnosis of pheochromocytoma . Circulation 21: 769, 1960.

Doyle, A.E. and Smirk, F.H. : Neurogenic component in hypertension . Circulation 12: 543, 1955.

Grob, D. , Scarborough, W.R. , Kaltus, H.A. , Jr. and Lonford, H.G. : Further observations on the effects of autonomic blocking agents in hypertension. II. Hemodynamic ballistocardiographic and electrocardiographic effects of hexamethonium and pentamethonium. Circulation 8: 352, 1953.

Schlittler, E. and Bein, H.J. : Rauwolfia alkaloids. In Antihypertensive Agents, edited by E. Schlittler. New York and London, Academic Press, 1967.

Sjoerdsma, A. , Vendsalu, A. and Engelman, K. : Studies on the metabolism and mechanism of action of methyldopa. Circulation 28: 492, 1963.

Maxwell, R.A. , Plummer, A.J. , Schneider , F. , Povalski, H. and Daniel, A.I. : Pharmacology of [2-(octohydro-1-azocinyl)-ethyl]-guanidine sulfate (SU-5864). J. Pharmacol. Exper. Therap. 128: 22, 1960.

Kopin, I.J. , Fischer, J.E. , Musacchio , J.M. and Wetlake, R.J. : False neurochemical transmitters and their relation to the hypotensive action of monamine oxidase inhibitors. J. Clin. Invest. 44: 10, 1965.

Engelman, K. , Portnoy, B. and Sjoerdsma, A. : Plasma catecholamine concentration in patients with hypertension. Circulation Res . 26/27 (Suppl. I): 141, 1970.

DeQuattro, V. and Chang, S. : Raised plasma-catecholamines in some patients with primary hypertension. Lancet 1: 806, 1972.

Bello, C. T.: Unpublished observations.

Louis, W.J. , Doyle, A.E. and Anevekar, S. : Plasma norepinephrine levels in essential hypertension. N. Engl. J. Med. 288: 599, 1973 .

Nestel, P.J. : Blood pressure and catecholamine excretion after mental stress in labile hypertension. Lancet 1: 692, 1969.

Lorimer, A.R. , MacFarlane, P.W. , Provan , G. , Duffy, T. and Larrie, T.D.V. : Blood pressure and catecholamine response to "stress" in normotensive and hypertensive subjects . Cardiovasc. Res. 5: 169, 1971.

McCubbin, J.W. , Green, J.H. and Page, I.H. : Baroreceptor functions in chronic renal hypertension. Circulation Res. 4: 205, 1956.

Bristow, J.D. , Honour, A.J. , Pickering , G.W. , Sleight, P. and Smyth, H.S. : Diminished baroreflex sensitivity in high blood pressure. Circulation 39: 48, 1969.

Vlachakis, N.D. , DeGuia, D. , Mendlowitz , M. , Wolf, R.L. and Antram, S. : Hypertension and anxiety. A trial with epinephrine and norepinephrine infusion. Mt. Sinai J. Med. (in press).

Vlachakis, N.D. , Schiavi, R. , DeGuia, D., Mendlowitz, M., Wolf, R. L.: Hypertension and anxiety. Am. Heart J. 87: 518, 1974.

Mendlowitz, M. and Naftchi, N. : Work of digital vasoconstriction produced by infused norepinephrine in primary hypertension. J. Appl. Physiol. 13: 247, 1958.

DeGuia, D. , Mendlowitz, M. , Gitlow, S.E. , Vlachakis, N.D. and Antram, S. : Testing in essential hypertension. A diagnostic approach. Vasa (in press).

Gitlow, S.E. , Mendlowitz, M. , Bertani , L.M. , Wilk, E.K. and Glabman, S. : Tritium excretion of normotensive and hypertensive subjects following administration of tritiated norepinephrine. J. Lab. Clin. Med. 73: 129, 1969.

Wolf, R.L. , Mendlowitz, M. and Roboz, J. : A new test for primary hypertension.: The apparent norepinephrine secretion rate in normotensive and hypertensive man. J. Clin. Invest. 46: 1134, 1967.

Suck, A.F. , Mendlowitz, M. , Wolf, R.L. , Gitlow, S.E. and Naftchi, N.E. : Identification of essential hypertension in patients with labile blood pressures . Chest 59: 402, 1971.

Wurtman, R.J. : Biogenic amines and endocrine function. Introduction: Neuroendocrine transducers and monamines. Fed. Proc. 32 (7): 1769, 1973.

Frohlich, E. , Tarazi, R. and Dustan, H.P. : Hyperdynamic β-adrenergic circulatory state. Arch. Int. Med. 123: 1, 1969.

DeGuia, D. and Mendlowitz, M.: Unpublished observations.

Biglieri, E.G. , Schambelan, M. , Skatorn , P.E. and Stockigt, J.R. : The intercurrent hypertension of primary aldosteronism. Circulation Res. 27 (Suppl. I): 195, 1970.

Laragh, J.H. , Ledingham, J.G.G. and Sommers , S.C. : Secondary aldosteromsm and reduced plasma renin in hypertensive disease. Trans. Ass. Amer. Phys. 80: 168, 1967.

Krakoff, L. R. and Mendlowitz, M.: Unpublished observations.

Winer, N. , Chokshi, D.S. , Yoon, M.S. and Freedman, A.D. : Adrenergic receptor mediation of renin secretion. J. Clin. Endocrinol. 29: 1168, 1969.

Bühler, R.F. , Baer, L. , Vaughn, E.D. , Brunner, H.R. and Laragh, J.H. : Inhibition of renin by propranolol. A specific treatment for renal hypertension ? Presented 64th Annual Meeting, Amer. Soc. Clin. Invest., May, 1972.

McCubbin, J.W. and Page, I.H. : Neurogenic component of chronic renal hypertension . Science 139: 210, 1963 .

Zimmerman, B.G. and Gomez, J. : Increased response to sympathetic stimulation in the cutaneous vasculature in the presence of angiotensin. Int. J. Neuropharmacol. 4: 185, 1965.

Stricker, J. , Mendlowitz, M. , Russo , C. , Gitlow, S. and Bertani, L.M. : The effect of continuous intravenous prostaglandin A1 infusion in patients with essential hypertension. Clin. Res. 19: 713, 1971.

Lee, J.B. , Attallah, A. , Vance, V.K. , Ellwood, C. and Prezyna, A. : Circulating prostaglandin A in human essential hypertension. J. Clin. Invest. 52: 50a, 1973.

Zusman, R. , Spector, D. , Caldwell, B. , Speroff, L. , Forman, B. , Schneider, G. and Mulrow, P. : Prostaglandin A concentration in plasma of normal and hypertensive humans . J. Clin. Invest. 52: 93a, 1973 .