Study On Peripheral Circulation Using Macroaggregated Serum Albumin Labelled With Radioactive Iodine

Abstract

The existence of anatomical and functional arteriovenous shunts was demon strated in the limbs by injecting radioiodinated macro-aggregated serum albu min into the feeding main artery. The size of shunt included those with about 20-50 μ. Consequently, the degree of shunt could be analyzed.

Scintiscanning after intraarterial injection of radioiodinated macroaggre gated serum albumin into the limb may be used as one of the ancillary methods for the diagnosis of peripheral vascular diseases. Especially, the study is useful when the findings are compared with that of peripheral arteriography.

In order to detect occlusions of arterial trees of the limbs without resorting to arteriography in those with peripheral arterial occlusive lesions, scanning of a suspected area of the extremities with a scintillation detector after injection of ¹³¹I labelled macroaggregated serum albumin (abbr. ¹³¹I MAA) into the main feeding artery was carried out. Occasionally, the site of occlusion of the main artery which was demonstrated by arteriography was consistent with the find ings by scintiscanning. ^1,2 However, the results were not highly successful. Jones et al³ in 1965 reported that when ¹³¹I MAA was injected into the femoral artery, normal and abnormal patterns of regional blood flow had been observed. In our study, it became obvious that regional blood flow was greatly influenced with the collaterals depending on the site, extent and period of occlusion. In this study, the anatomical and functional collateral blood flow in man with occlu sive vascular disease will be described.

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References

I. Ohara , H. Ouchi , H. Shida and K. Kamimura : Evaluation of Peripheral Vascular Occlusion by Scanning with Radioactive Iodinated Macroaggregated Serum Albumin. Read at the 34th Local Meeting of the Japan Circulation Society, Sendai , Feb. 10, 1968.

I. Ohara , H. Ouchi , and H. Shida : A Study of Collaterals in the Limbs Using Mascoaggregated Serum Albumin Labelled with Radioactive Iodine. Read at the 9th General Meeting of the Japan Angiology Society, November 15, Tokyo , 1968.

Jones, E.L. , Wagner, H.N. Jr., and Zuidema, G.D. : New Method for Studying Peripheral Circulation in Man, Arch. Surg., 1965, 91, 725-734.

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