In a study of physical and nutritional characteristics of cases of coronary heart disease, it was found that a large number of patients had low intake of fat, about 50 gm per day, and their carbohydrate intake was high. As a result high-carbohydrate diet was considered to be a possible factor in atherosclerosis. Yudkin also incriminated sugars in the causation of coronary atherosclerosis. Therefore a study was planned to assess the effect of high-carbohydrate diet on coronary arteries of rabbits. In this experiment it was decided to study the effect of high-carbohydrate diet alone on lipid fractions in the blood and the effects on coronary arteries and aorta when added fats are not given.
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