Systemic Toxicity of Ca-7 (Fibrinolytic Enzyme From Aspergillus Oryzae) in the Dog

Tosoni, A.L. , and Glass, D.G. : Production of fibrinolytic material from strains of Aspergillus. Canadian patent no. 671647, Oct. 1, 1963.

Tosoni, A.L. , and Ives, D.A.J. : Production of high-activity fibrinolytic agents. Canadian patent no. 671648, Oct. 1, 1963, and U. S. patent no. 3140984, July 14, 1964.

Roschlau, W.H.E. : The evaluation in the dog of a proteolytic enzyme derived from Aspergillus oryzae. Canad. J. Physiol. & Pharmacol., 42: 109, 1964.

Roschlau, W.H.E. , and Tosoni, A.L. : Thrombolytic therapy with CA-7 (fibrinolytic enzyme from Aspergillus oryzae) in the dog. Canad. J. Physiol. & Pharmacol., 43: 731, 1965.

Roschlau, W.H.E. : Natural protease resistance to CA-7 (fibrinolytic enzyme from Aspergillus oryzae) in the dog. Canad. J. Physiol. & Pharmacol., 43: 741, 1965.

Roschlau, W.H.E. , and Fisher, A.M. : Thrombolytic therapy with local perfusions of CA-7 (fibrinolytic enzyme from Aspergillus oryzae) in the dog . Angiology, 17: 670, 1966.

Giering, J.E. , and Truant, A.P. : An experimental method for quantitative evaluation of thrombolysis: Effect of CA-7, a protease from Aspergillus oryzae . Angiology, 17: 661, 1966.

Bergkvist, R. , and Svärd, P.O. : Studies on the thrombolytic activity of a protease from Aspergillus oryzae. Acta physiol. scandinav. , 60: 363, 1964.

Bergkvist, R. : The proteolytic enzymes of Aspergillus oryzae. IV. On the inhibition of the enzymes by serum. Acta chem. scandinav., 17: 2239, 1963.

Stefanini, M. , and Karaca, M. : Natural inhibitors of fungal protease (Aspergillin O). Ann. New York Acad. Sc., 103: 803, 1963 .

Monkhouse, F.C. , Daramola, F. , and Gillespie, R.J. : The action of a proteolytic enzyme from Aspergillus oryzae on components of the blood clotting system. Canad. J. Physiol & Pharmacol., 42: 377, 1964.