Thrombolytic Therapy with Local Perfusions of Ca-7 (Fibrinolytic Enzyme from Aspergillus Oryzae) in the Dog

Tosoni, A. L., and Glass, D. G.: Production of fibrinolytic material from strains of Aspergillus. Canadian patent No. 671647, Oct. 1, 1963.

Tosoni, A. L., and Ives, D. A. J.: Production of high-activity fibrinolytic agents. Canadian patent No. 671648, Oct. 1, 1963, and U.S. patent No. 3140984, July 14, 1964.

Roschlau, W.H.E. : The evaluation in the dog of a proteolytic enzyme derived from Aspergillus oryzae. Canad. J. Physiol. Pharmacol., 42: 109, 1964.

Roschlau, W.H.E. : Natural protease resistance to CA-7 (fibrinolytic enzyme from Aspergillus oryzae) in the dog. Canad. J. Physiol. Pharmacol., 43: 741, 1965.

Roschlau, W.H.E. , and Tosoni, A.L. : Thrombolytic therapy with CA-7 (fibrinolytic enzyme from Aspergillus oryzae) in the dog. Canad. J. Physiol Pharmacol., 43: 731, 1965.

Bergkvist, R. : The proteolytic enzymes of Aspergillus oryzae. IV. On the inhibition of the enzymes by serum. Acta chem. scandinav., 17: 2239, 1963.

Bergkvist, R. , and Svärd, P.O. : Studies on the thrombolytic activity of a protease from Aspergillus oryzae. Acta physiol. scandinav., 60: 363, 1964.

Stefanini, M. , and Karaca, M. : Natural inhibitors of fungal protease (Aspergillin O). Ann. New York Acad. Sc. 103: 803,1963.

Monkhouse, F.C. , Daramola, F. , and Gillespie, R.J. : The action of a proteolytic enzyme from Aspergillus oryzae on components of the blood clotting system. Canad. J. Physiol. Pharmacol., 42: 377, 1964.

Mazel, M.S. , Bolton, H.E. , Stern, J.R. , Riera, R. , and Cabral, H. : Coronary arterial and other intravascular thromboses treated with fibrinolysin. Angiology, 14: 88, 1963.

McNicol, G.P. , Reid, W. , Bain, W.H. , and Douglas, A.S. : Treatment of peripheral arterial occlusion by streptokinase perfusion. Brit. M. J., 1: 1508, 1963.

McNicol, G.P. , and Douglas, A.S. : Treatment of peripheral vascular occlusion by streptokinase perfusion. Scand. J. Clin. Lab. Invest., 16: Supp. 78, 23, 1964.

Verstraete, M. , Amery, A. , and Vermylen, J. : Feasibility of adequate thrombolytic therapy with streptokinase in peripheral arterial occlusions. Brit. M. J. 1: 1499, 1963.

Atkin, N. , Nitzberg, S. , and Dorsey, J. : Lysis of intracerebral thromboembolism with fibrinolysin. Angiology, 15: 436, 1964.

Dyer, A.E. , and Kadar, D. : Fibrin suspension assay for fibrinolytic activity. Blood, 23: 729, 1964.

Roschlau, W.H.E. , and Painter, R.H. : Human fibrinolysin with and without urokinase: its effect on experimental arterial thrombi in dogs. Canad. J. Biochem. Physiol., 40: 1819, 1962.

Cox, E.F. , Flotte, C.T. , and Buxton, R.W. : Dextran in the treatment of thrombophlebitis. Surgery, 57: 225, 1965.

Sawyer, R.B. , Moncrief, J.A. , and Canizaro , P.C. : Dextran therapy in thrombophlebitis. J. A. M. A., 191: 740, 1965 .