A Long-Term Therapy of Ischemic Heart Disease

Elliot, E.C. : The effect of Persantin on coronary flow and cardiac dynamics. Canad. M. A. J., 85: 469, 1961.

Grabner, G. , Kaind, F. , AND Kraupp, O. : The effect of 2,6-bis(diethanolamino)-4,8-dipiperidino-pyrimido [5,4-d] pyrimidine on cardiac activity and coronary circulation in anesthetized dogs. Arzneimittel-Forsch., 9: 45, 1959.

Feruglio, F.S. , Migheli, B. , Campus, S. , Pandolfo, G. , AND Accatino, G. : Studies on the circulation in the organs; effect of 2,6-bis[di-(α-hydroxyethyl)amino]-4,8-dipiperidine-pyrimido[5,4-d]pyrimidine on the coronary circulation of the dog. Minerva med., 51: 3793, 1960.

Wendt, V.E. , Sundermeyer, J.F. , Den-Bakker, P.B. AND Bing, R.J. : The relationship between coronary blood flow, myocardial oxygen consumption and cardiac work as influenced by Persantin. Am. J. Cardiol. , 9: 449, 1962.

West, J.W. , Bellet, S. , Manzoli, V.C. , AND Mueller, O.F. : Effects of Persantin (RA 8), a new coronary vasodilator, on coronary blood flow and cardiac dynamics in the dog. Circulation Res., 10: 35, 1962.

Betz, E. , ET AL: Measurement of myocardial blood flow with the thermal conductivity probe with regard to the effect of Persantin. 27th Congress Circulation Bad Nauheim, p. 321, 1961.

Dorner, J. , AND Wick, E. : Comparative investigations into the efficacy of commonly used coronary vasodilator drugs in anesthetized and unanesthetized dogs. Arzneimittel-Forsch. , 10: 631, 1960.

Kadatz, R. : The pharmacology of 2,6-Bis (diaethanolamino)-4, 8-dipiperidino-pyrimido(5,4-d)pyrimidine, a new compound with coronary-dilatory properties. Arzneimittel-Forsch. , 9: 39, 1959.

Menge, H.G. , AND Kadatz, R. : Correlations between chemical structure and vasodilator action in pyrimido (5,4-d) pyrimidine derivates. Arzneimittel-Forsch., 9: 476, 1959. 10. Bretschneider, H.J. , Frank, A. , Bernard, V. , Kochsiek, K. , AND Scheler, F. : Effect of a pyrimidopyrimidine derivate on oxygen supply to the myocardium. Arzneimittel-Forsch., 9: 49, 1959.

Hockerts, T. , AND Bögelmann, G. : Studies of the action of 2,6-bis-(diethanolamino)-4,8-dipiperidino-pyrimido (5,4-d) pyrimidine on the heart and circulation. Arzneimittel-Forsch. , 9: 47, 1959.

Betz, E. , Braasch, D. , AND Hensel, H. : The action of 2,6-bis-(diethanolamino)-4,8 dipiperidino-pyrimido(5,4-d) pyrimidine on the blood flow of the myocardium, brain, kidney, liver, skin and skeletal muscles. Arzneimittel-Forsch., 11: 333, 1961.

Bernsmeier, A. , AND Rudolph, W. : Myocardial metabolism. 27th Congress, German Society for Circulation Research, Bad Nauheim, p. 74, 1961.

Kinsella, D. , Troup, W. , AND Mcgregor, M. : Studies with a new coronary vasodilator drug: Persantin. Am. Heart J., 63: 146, 1962. 15. Peel, A.A.F. , Blum, K. , Lancaster, W.M. , Dall, J.L. , AND Chalmers, G.L. : Observations on the coronary vasodilator effect of Persantin. Scot. M. J., 6: 403, 1961.

Knipping, H.W. , Bolt, W. , AND Mikuliez, K. : Clinical experiences and experimental studies on a new pyrimido-pyrimidine derivative. Arzneimittel-Forsch. , 10: 364, 1960.

Thorn, W. : Metabolitkonzentrationen im Herzmuskel unter normalen, hypoxischen und anoxischen Bedingungen; Verhandlungen der Deutschen Gesellschaft für Kreislaufforschung . 27th Congress, German Society for Circulation Research, Bad Nauheim, p. 82, 1961.

Siess, M. : Funktion und Energiestoffwechsel des erschöpften Herzmuskels unter der Wirkung von 2,6-Bis-(diaethanolamino)-4,8-dipiperidino-pyrimido (5,4-d) pyrimidin . Arzneimittel-Forsch., 12: 683, 1962.

Lamprecht, W. : Stoffwechsel, Energetik und regulatorische Mechanismen der Herzmuskelzelle; Verhandlungen der Dutschen Gesellschaft für Kreislaufforschung. 27th Congress, German Society for Circulation Research, Bad Nauheim, p. 16, 1961.

Siess, M. : Investigations to influence the energy metabolism in the exhausted auricular preparation. 27th Congress, German Society for Circulation Research, Bad Nauheim, p. 259, 1961.

Laudahn, G. : The effect of Persantin upon heart muscle sarcomas . Experientia, 17: 415, 1961.

Hasselbach, W. : Contractile structures of cardiac muscle and contraction cycle. 27th Congress, German Society for Circulation Research, Bad Nauheim, p. 115, 1961.

Hochrein, H. , Schneider, K.W. , AND Sell, R. : Uber die Wirkung von 2,6-Bis (diathanolamino)-4,8 dipiperidinopyrimido (5, 4-d) pyrimidin auf das sufflziente und insuffiziente Herz. Nauny-Schmiedebergs Arch. exper. Path. u. Pharmakol. , 243: 119, 1962.

Wezler, K. : The action of 2,6-bis-(diethanol-amino)-4,8-dipiperidino-pyrimido (5,4-d) pyrimidine upon the dynamics of the isolated, spontaneously-beating, cold blooded heart. Arzneimittel-Forsch., 11: 943, 1961.

Kiese, M. , Lange, G. , AND Resag, K. : The effect of 2,6-bis-(diethanolamino)-4,8-dipiperidino-pyrimido (5,4-d) pyrimidine on blood flow through the experimental myocardial infarct and normal heart muscle. Ztschr. ges. exper. Med., 132: 426, 1960 .

Gebhardt, W. : The action of 2,6-bis-(diethanolamino)-4,8-dipiperidino- pyrimido (5,4-d) pyrimidine upon the dynamics of the isolated, spontaneously beating, warm-blooded heart. Arzneimittel-Forsch., 11: 957, 1961.

Gebhardt, W. , Dressel, J. , Steim, H. , AND Reindell, H. : Circulatory effects of 2,6-bis-(diethanolamino)-4,8-dipiperidino-pyrimido (5,4-d) pyrimidine upon the circulation. Arzneimittel-Forsch. , 11: 962, 1961.

Kadatz, R. , AND Schröter, H.W. : Experimental studies on a new drug for heart therapy. Medecine et Hygiene, 541: 233, 1962.

Laurent, D. , Chevrier, J.L. , AND Mouquin, M. : Experimental study of the effects of Persantin on coronary circulation and on myocardial metabolism under basal conditions. Presse méd., 69: 2292, 1961.

Pillat, B. : The influence of Persantin on the action potential of the papillary muscle in the cat. Nauny-Schmiedebergs Arch. exper. Path. u. Pharmakol. , 241: 467, 1961.

Kunz, W. , AND Siess, M. : Energy gain in cardiac muscle with a hydrogen transferring pyrimidine derivative . Nauny-Schmiedebergs Arch. exper. Path. u. Pharmakol., 241: 529, 1961.

Kanther, R. : Die kardiogene Hyperpyruviamie als Ausdruck der Myokardstoffwechselstörung und ihre medikamentose Beeinflussung. München. med. Wchnschr., 104: 40, 1962.

Albach, E. : The behavior of lactic acid (LA), pyruvic acid (PA), and transaminase (SGOT and SGPT) in cardiac patients treated with Persantin. Med. Welt, 2: 993, 1960.

Greif, S. : Clinical and experimental studies to determine the effect of Persantin in coronary disease. Wien. med. Wchnschr., 110: 463, 1960 .

Adlam, J.P. : Persantin. Brit. M. J., 5240: 1686, 1961.

Leimgardt, H. : A contribution to the treatment of coronary insufhciency. Medizinische, 49: 2408, 1959 .

Geschke, H.J. : Clinical experiences with Persantin in cardiac disease. Landarzt, 36: 876, 1960.

Röseler, E. : Clinical experiences with Persantin in the treatment of coronary and myocardial insufficiency. Med. Welt, 2: 2562, 1960.

Fischer, K.K. , AND Fiegel, C. : Increase in oxygen supply to the myocardium by use of the pyrimido-pyrimidine group. Deutsche. med. J. , 10: 484, 1959.

Junemann, P. : Persantin, a new compound for the treatment of coronary insufficiency. München med. Wchnschr., 101: 340, 1959.

Peel, A.A.F. : Persantin. Brit. M. J., 5237: 1461, 1961 .

Tetzlaff, H. , AND Tetzlaff, D. : Treatment of coronary insufficiency with Persantin. Med. Monatsschr., 13: 229, 1959.

Dütsch, L. : Coronary insufficiency. Therap. Gegenw., 99: 228, 1960.

De Castro, B. , AND Parchi, C. : Preliminary results of tests with a new coronary dilator derived from pyrimido-pyrimidine (RA 8). Gior. clin. med., 41: 769, 1960.

Bambor, H.J. : A contribution to the treatment of coronary circulatory disturbances. Med. Klinik., 55: 1155, 1960 .

Hamm, J. , Renschler, H.E. , AND Zack, W.J. : Clinical studies on the action of Persantin in angina pectoris. Medizinische, 3: 120, 1959.

Lang, O. : Treatment of coronary insufficiency with 2,6-bis-(diethanolamino)-4,8-dipiperidino-pyrimido (5,4-d) pyrimidine. Wien. med. Wchnschr., 50: 1006, 1959 .

Pabst, H.W. : The action of a new coronary dilator 2,6-bis-(diethanolamino)-4,8-dipiperidino-pyrimido (5,4-d) pyrimidine. Med. Klinik., 54: 257, 1959.

Spitzbarth, H. : A study of the circulatory and clinical effects of 2,6-bis-(diethanol-amino)-4,8-dipiperidino-pyrimido (5,4-d) pyrimidine . Arzneimittel-Forsch., 9: 59, 1959.

Cova, N. , AND Bregani, P. : Some preliminary observations on the use of a new coronary dilator (RA 8) in the coronary insufficiency syndrome. Minerva cardioangiol. , 8: 431, 1960.