Thyroid Analogs as Cholesteropenic Agents

Mussett, M.V. , AND Pitt-Rivers , R. : The physiologic activity of thyroxine and triiodothyronine analogues. Metabolism, 6: 18, 1957.

Greene, R. , AND Farran, H.E.A. : Physiological activity of d-thyroxine. Brit. M. J. , 2: 1057, 1958.

Starr, P. : Depression of the serum cholesterol in myxedematous patients by an oral dosage of sodium dextro-thyroxine which has no effect on basal metabolic rate or electrocardiogram. J. Clin. Endocrinol., 20: 116, 1960.

Starr, P. , Roen, P. , Freibrun, J.L. , AND Schleissner, L.A. : Reduction of serum cholesterol by sodium dextro-thyroxine . A. M. A. Arch. Int. Med., 105: 830, 1960 .

Cohen, B.M. , AND Bindelglass, I.L. : Sodium dextro-thyroxine in the therapy of hypercholesterolemia . Clin. Med., 7: 1871, 1960.

Oliver, N.F. , AND Boyd, G.S. : Reduction of serum cholesterol by dextro-thyroxine in men with coronary heart disease. Lancet , 2: 783, 1961.

Investigational use circulars, SKF D-2623, October 1959, March 1960. Smith, Kline & French Laboratories, Philadelphia.

Symposium on sodium d-thyroxine, December 5, 1959, Baxter Laboratories, Inc., Chicago.

Page, I.H. , AND Connor, L.A. : Memorial lecture; atherosclerosis; introduction. Circulation , 10: 1, 1954.

Tobian, L. , AND Tuna, N. : The efficacy of corn oil in lowering the serum cholesterol of patients with coronary atherosclerosis. Am. J. Ed. Sc., 235: 133, 1958 .

Parsons, W.B. , JR. : Use of aluminum nicotinate in hypercholesterolemia . Current Therap. Res., 2: 137, 1960.

Hollander, W. , Chobamon, A.V. , AND Wilkins, R.W. : The effects of an inhibitor of cholesterol biosynthesis, triparanol (MER/29) in subjects with and without coronary artery disease. Circulation, 20: 713, 1959.

Corcoran, A.C. : Coronary atherosclerosis— status of MER/29 (Triparanol). Am. Heart J., 61: 431, 1961.

Schoenheimer, R. , AND Sperry, W.M. : Micromethod for determination of free and combined cholesterol. J. Biol. Chem., 106: 745, 1934 .

Brown, H. , Reingold, A.M. , AND Samson, M. : The determination of protein-bound iodine by dry ashing. J. Clin. Endocrinol., 13: 444, 1953.

Memorandum to Smith, Kline & French D-2623 project team , October 12, 1960, Smith, Kline & French Laboratories, Philadelphia.

Cole, S.L. , Kaye, H. , AND Griffith, G.C. : Assay of antianginal agents. I. A curve analysis with multiple control period . Circulation, 15: 405, 1957.

Cole, S.L. , Kaye, H. , AND Griffith, G.C. : Assay of anti-anginal agents: The rapport period. J. A. M. A., 168: 275, 1958.

Thomas, C.B. , AND Murphy, E.A. : Further studies on cholesterol levels in the Johns Hopkins medical students. The effect of stress at examination . J. Chron. Dis., 8: 661, 1958.

Grundy, S.M. , AND Griffin, A.C. : Relationship of periodic mental stress to serum lipoprotein and cholesterol levels. J. A. M. A., 171: 1794, 1959.

Thomas, C.B. , Holljis, H.W. , AND Eisen-Berg , F.F. : Observation on seasonal variations in total serum cholesterol levels among healthy young persons. Ann. Int. Med., 54: 413, 1961.

Tapley, D.F. , Davidoff, E.F. , Hatfield , W.B. , AND Ross, J.E. : Physiological disposition of D- and L-thyroxine in the rat. Am. J. Physiol. , 197: 1021, 1959 .

Greer, M.A. : The effect on endogenous thyroid activity of feeding desiccated thyroid to normal human subjects. New England J. Med., 244: 385, 1951.

Slater, S. , Perlmutter, M. , Paz-Carranza, J. , AND Numeroff, M. : The effects of several thyroxine analogues upon the thyroidal uptake in man . J. Clin. Endocrinol., 20: 401, 1960.

Brown-Grant, K. : The "feedback" hypothesis of the control of thyroid function. Colloquia on endocrinology—"Regulation and mode of action of thyroid hormones," 10: 97, 1959.

Gltrling, K.J. , Baron, D.M. , AND Radley-Smith , E.J. : Thyroid adenomas and thyrotoxicosis in patients with hypopituitarism following hypophysectomy . J. Clin. Endocrinol., 19: 717, 1959.

Pazianos, A.G. , BENVA, R., RAY, B. S., AND PEARSON, O. H.: Persistent thyroid function following hypophysectomy. J. Clin. Endocrinol., 20: 1051, 1960.

Strisower, B. , Gofman, J.W. , Galione . E.F. , Reisinger, J.H. , Pouteau, J. , AND Guzvich, P. : Long-term effect of dried thyroid on serum lipoprotein and serum-cholesterol levels. Lancet, 1:120, 1957.

Rosenman, R.H. , Byers, S.O. , AND Friedman , M. : The mechanism responsible for altered blood cholesterol content in deranged thyroid states . J. Clin. Endocrinol., 12: 1287, 1952.

Siperstein, M.D. , AND Murray, A.W. : Cholesterol metabolism in man . J. Clin. Invest., 34: 1449, 1955.

Leroy, G.V. : Studies of Cholesterol synthesis in man using carbon 14 labelled acetate . Ann. Int. Med., 44: 524, 1956.

Gould, R.G. , AND Leroy, G.V. : The use of C-14 labeled acetate to study cholesterol metabolism in man. J. Lab. & Clin. Med., 46: 372, 1955.

Hellman, L. , Rosenfeld, R.S. , AND Gallag-Her , T.F. : Cholesterol synthesis from C-14 acetate in man. J. Clin. Invest., 33: 142, 1954.

Kurland, G.S. , Lucus, J.L. , AND Freed-Berg , A.S. : The metabolism of intravenously infused C-14 labeled cholesterol in euthyroidism and myxedema . J. Lab. & Clin. Med., 57: 574, 1961.

Jones, R.J. , Cohen, L. , AND Corbus, H. : The serum lipid pattern in hyperthyroidism, hypothyroidism, and coronary atherosclerosis. Ann. New York Acad. Sc., 72: 980, 1959.

Gould, R.G. : Lipid metabolism and atherosclerosis. Am. J. Med., 11: 209, 1951.