The Physiologic Protective Mechanism Against Intravascular Clotting*†

Quick, A.J. : Studies on the enigma of the hemostatic dysfunction of hemophilia. Am. J. M. Sc., 214: 272, 1947.

Schulman, I. , AND Smith, C.H. : Hemorrhagic disease in an infant due to deficiency of a previously undescribed clotting factor. Blood, 7: 794, 1952.

Aggeler, P.M. , White, S.G. , Glendening, M.B. , Page, E.W. , Leake, T.B. , AND Bates, G. : Plasma thromboplastin component (PTC) deficiency; a new disease resembling hemophilia. Proc. Soc. Exper. Biol. & Med., 79: 692, 1952.

Biggs, R. , Douglas, A.S. , Macfarlane, R.G. , Dacie, J.V. , Pitney, W.R. , Merskey, C. AND O'Brien, J.R. : Christmas disease, a condition previously mistaken for hemophilia. Brit. M. J., 2: 1378, 1952.

Quick, A.J. : The hereditary hemorrhagic diseases ; their classification and diagnosis. Brit. M. J., 1: 1059, 1959.

Quick, A.J. , Hussey, C.V. , AND Epstein, E. : Activation of thromboplastinogen by thrombin. Am. J. Physiol. , 174: 397, 1953.

Quick, A.J. : The normal antithrombin of the blood and its relation to heparin. Am. J. Physiol., 123: 712, 1938.

Usteri, C. : Das Heparinkomplement und seine physiologisch-klinische Bedeutung. Inauguration Dissertation, Zurich, 1949.

Lyttleton, J.W. : The antithrombic activity of heparin. Biochem. J., 58: 15, 1954.

Monkhouse, F.C. , France, E.S. , AND Seegers, W.H. : Studies on the antithrombin and heparin cofactor activities of a fraction adsorbed from plasma by aluminum hydroxide . Circulation Res., 3: 397, 1955.

Quick, A.J. , AND Hussey, C.V. : Hyperheparinemia, report of a case. Am. J. M. Sc., 234: 251, 1957.

Foa, C. : Sulle leggi d'azione della trombina. Arch. fisiol., 10: 479, 1912.

Quick, A.J. , AND Favre-Gilly, J. : Fibrin, a factor influencing consumption of prothrombin in coagulation. Am. J. Physiol., 158: 387, 1949.

Quick, A.J. : On the probable mechanism of intravascular clotting. Angiology, 7: 419, 1956.

Quick, A.J. , Hussey, C.V. , Harris, J. , AND Peters, K. : Effect of injecting thrombin intravenously . Fed. Proc., 18: 305, 1959.

Epstein, E. , AND Quick, A.J. : Effect of injecting platelet extract intravenously. Proc. Soc. Exper. Biol. & Med., 83: 463, 1953.

Quick, A.J. , Georgatsos, J.G. , AND Hussey, C.V. : The clotting activity of human erythrocytes; theoretical and clinical implications. Am. J. M. Sc., 228: 207, 1954.

Quick, A.J. , AND Stefanini, M. : The concentration of the labile factor of the prothrombin complex in human, dog and rabbit blood; its significance in the determination of prothrombin activity. J. Lab. & Clin. Med., 33: 819, 1948.