Early Experience With Fibrinolysin

Cliffton, E.E. , Grossi, C.E. , AND Cannamela , D.A. : Lysis of thrombi produced by sodium morrhuate in the femoral vein of dogs by human plasmin (fibrinolysis). Ann. Surg., 139: 52, 1954.

Grossi, C.E. , Cliffton, E.E. , AND Cannamela , D.A. : The lysis of intravascular thrombi in rabbits with human plasmin (fibrinolysin). Blood , 9: 310, 1954.

Cliffton, E.E. , AND Grossi, C.E. : Investigations of intravenous plasmin (fibrinolysin) in humans; physiologic and clinical effects. Circulation, 14: 919, 1956.

Cliffton, E.E. : The use of plasmin in humans. Ann. New York Acad. Sc., 68: 209, 1957.

Cliffton, E.E. : The use of plasmin in the treatment of intravascular thromboses. J. Am. Geriatrics Soc., 6: 118, 1958.

Moser, K.M. : Thrombolysis with fibrinolysin (plasmin)—new therapeutic approach to thromboembolism. J. A. M. A., 167: 1695, 1958 .

Johnson, A.J. , Mccarthy, W.R. , AND Tillett, W.S. : The lysis of artificially induced intravascular clots in man by intravenous infusion of purified streptokinase. 44th Clinical Congress of the American College of Surgeons, Chicago, 1958.

Macfarlane, R.G. , AND Biggs, R. : Observations on fibrinolysis; spontaneous activity associated with surgical operations, trauma, etc. Lancet, 2: 862, 1946.

Tagnon, H.J. , Levenson, S.M. , Davidson , C.S. , AND Taylor, F.H.L. : The occurrence of fibrinolysis in shock, with observations on the prothrombin time and the plasma fibrinogen during hemorrhagic shock, Am. J. M. Sc., 211: 88, 1946.

Mole, R.H. : Fibrinolysin and the fluidity of the blood postmortem. J. Path. & Bact., 60: 413, 1948.

Scroggie, A.E. , Jacques, L.B. , AND Rocha E Silva , M. : Activation in peptone shock. Proc. Soc. Exper. Biol. & Med., 66: 326, 1947.

Fantl, P. , AND Simon, S.E. : Fibrinolysis following electrically induced convulsions. Australian J. Exper. Biol. & M. Sc., 26: 521, 1948.

Christensen, L.R. , AND Mcleod, C.M. : Proteolytic enzyme of serum; characterization, activation and reaction with inhibitors. J. Gen. Physiol. , 28: 559, 1945.

Milstone, H.J. : Factor in normal human blood which participates in streptococcal fibrinolysis, J. Immunol., 42: 109, 1941.

Gerheim, E.B. , Ferguson, J.H. , Travis , B.L. , Johnson, C.L. , AND Boyles, P.W. : Staphylococcal fibrinolysis. Proc. Soc. Exper. Biol. & Med., 68: 246, 1948.

Cliffton, E.E. , AND Cannamela, D.A. : Variations in proteolytic activity of serum of animals including man as activated by staphylokinase and streptokinase. Proc. Soc. Exper. Biol. & Med., 77: 305, 1951.

Astrup, T. : The activation of a proteolytic enzyme in blood by animal tissue. Biochem. J., 50: 5, 1951.

Astrup, T. , Fibrinokinase. Acta physiol. scandinav., 24: 267, 1951.

Astrup, T. , AND Stage, A. : Isolation of a soluble fibrinolytic activator from animal tissue. Nature, 170: 929, 1952.

Mullertz, S. : A plasminogen activator in spontaneously active human blood. Proc. Soc. Exper. Biol. & Med., 82: 291, 1953.

Astrup, T. , AND Sterndorff, I. : An activator of plasminogen in normal urine. Proc. Soc. Exper. Biol. & Med., 81: 675, 1952.

Mullertz, S. , AND Lassen, M. : An activator system in blood indispensable for formation of plasmin by SK. Proc. Soc. Exper. Biol. & Med., 82: 264, 1953.

Mullertz, S. : Formation and properties of the activator of plasminogen and of human and bovine plasmin. Biochem. J. , 61: 424, 1955.

Sherry, S. : The fibrinolytic activity of streptokinase activated human plasmin . J. Clin. Invest., 33: 1054, 1954.

Ablondi, F.B. , AND Hagen, J.J. : Stability of the activation of bovine plasminogen. Proc. Soc. Exper. Biol. & Med. , 93: 414, 1956.

Kline, D.L. , AND Fishman, J.B. : Plasmin: the humoral protease. Ann. New York Acad. Sc., 68: 25, 1957.

Siegel, M. , AND Cliffton, E.E. : Mechanism of in vitro activation of human fibrinolytic system: differential titration of the components. J. Appl. Physiol., 10: 289, 1957.

Freiman, A. , Bang, N. , Ruegsegger, P. , Nydick, I. , AND Cliffton, E.E. : The lysis of intravascular clots with fibrinolysin (human plasmin) ; the dissolution of recently formed serum clots in animals.

Freiman, A.H. , AND Cliffton, E.E. : The effect of fibrinogen concentration on susceptibility of clots to in vitro clot lysis with plasmin. Thrombosis et diathesis haemorrhagica, 2: 269, 1958.