Rational Elimination of Side Reactions and/or Tolerance in the Development of Potentially Valuable Drugs

Grimson, K.S. , Reardon, M.J. , Marzoni , F.A. AND Hendrix, J.P. : The Effects of Priscol (2-benzyl-4,5-imidazoline HCl) on Peripheral Vascular Diseases, Hypertension and Circulation in Patients . Ann. Surg., 127: 968, May 1948.

Yonkman, F.F. , Hays, H.W. , Cameron , A. , Pellet, E. AND Hansen, N. : Cholinergic Action of the Antisympathetic Agent Priscol (benzylimidazoline HCl). Federation Proc., 5: 216, March 1946.

Hargraves, M.M. : Transfusion Reactions and Their Treatment. Medical Clinics of North America, 31: 802, July 1947.

Gross, F. , Druey, J. AND Meier, R. : A New Group of Depressor Substances with a Special Type of Effect . Experientia, 6: 19, 1950.

Craver, B.N. AND Yonkman, F.F. : Some Pharmacological Properties of 1-hydrazinophthalazine, a Hypotensive Agent . Federation Proc., 9: 265, March 1950.

Freis, E.D. AND Finnerty, JR., F.A. : Suppression of Vasomotor Reflexes in Man Following 1-hydrazinophthalazine (C-5968). Proc. Soc. Exper. Biol. and Med., 75: 23, October 1950.

Plummer, A.J. AND Wagle, G. : To be published.

Craver, B.N. , Barrett, W. , Cameron, A. AND Yonkman, F.F. : The Activities of 1-hydrazinophthalazine (Ba-5968), a Hypotensive Agent. J. Am. Pharm. A. (Scient. Ed.) 40: 559, Nov. 1951.

Graham, J.R. AND Wolff, H.G. : Mechanism of Migraine Headache and Action of Ergotamine Tartrate. Arch. Neurol. and Psychiat. , 39: 737, April 1938.

Prandoni, A.G. : Personal communication.

Wolf, S. : Personal communication.

Schroeder, H.A. : Effect of 1-hydrazinophthalazine in Hypertension. Preliminary Report. Circulation, in press.

Rogers, M.P. and Yonkman, F.F. : Adrenergic Blocking Agents: Their Use in Clinical Medicine. Am. J. Digest. Dis., in press.

Horton, B.T. : The Use of Histamine in the Treatment of Specific Types of Headaches. J.A.M.A., 116: 377, February 1, 1941.

Yonkman, F.F. : Neurogenic Hypertension: Chemical Approaches to Its Amelioration. J. Michigan M. Soc., 50: 160, February 1951.

Freis, E.D. , Finnerty, JR., F.A. AND Walsh, W.B. : The Treatment of Severe Essential Hypertension. Medical Clinics of North America, 34: 1741, November 1950.

Freis, E.D. , Finnerty, JR., F.A. , Johnson, R.L. AND Schnaper, H.W. : The Treatment of Hypertension with Hexamethonium. To be published.

Freis, E.D. : Letter to the editor. Lancet 1: 909, 1951.

Bein, H.J. AND Meier, R. : Zur Pharmakologie des N,N,N',N'-3-Pentamethyl-N,N'diäthyl-3-aza-pentan-1,5-diammonium-dibromid (C-9295), einer ganglionär hemmenden Substanz. Experientia , 6: 351, 1950.

Medical Economics, 22: 84, April 1945 (Quotes figures from U. S. Census Bureau).