Chemical adhesive closure (CAC) has comparable efficacy to thermal ablation but with faster recovery. Endovenous glue-induced thrombosis (EGIT) is a rare complication after CAC with lacking data regarding the prevalence and potential associations with deep vein thrombosis (DVT) and pulmonary embolism (PE). A retrospective chart analysis of patients treated with CAC at our institution between January 2018 and May 2022 was completed. Data collected included demographics, site and severity of chronic venous insufficiency (CVI), procedure details and outcomes at follow up visit. A comprehensive literature search of PubMed/Medline, Embase, and Cochrane was then conducted on December 2022, to include all studies that reported EGIT cases. The search generated 19 previous studies with a total of 2101 patients treated using CAC. The pooled prevalence rate of EGIT across these studies was 1.2% (95% CI: 0.3%–2.1%, I2 = 61.1%). There were two reported cases of CAC-related DVT and no related cases of PE. In our patient cohort, age, treated vein size or procedure complexity were not significantly associated with increased risk of EGIT. CAC is an effective treatment for CVI with a low prevalence of EGIT. There were two reported cases of CAC-related DVT and no PE.
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