Study on 295 consecutive medical patients to evaluate the potential of routine blood tests to identify the risk of deep vein thrombosis (DVT). The tests included in a DVT risk stratification model system were erythrocyte sedimentation rate, antithrombin III, C-reactive protein, D-dimer, and N-terminal pro-brain natriuretic peptide. The DVT risk stratification system was moderately prognostic (area under the curve: 0.838; 95% confidence interval: 0.771-0.904; P < .001), whereas its performance was as follows—sensitivity, 100%; specificity, 20%; positive predictive value, 21%; and negative predictive value, 100%. The prevalence of DVT and DVT + superficial thrombophlebitis was 7.5% and 3.1%, respectively. These routine blood tests may prove helpful to stratify the DVT risk in medical patients.
AndersonFAJrWheelerHBGoldbergRJ. A population based perspective of the hospital incidence and case-fatality rates of deep vein thrombosis and pulmonary embolism. The Worcester DVT Study. Arch Intern Med. 1991;151(5):933–938.
2.
LindbladBSternbyNHBergqvistD. Incidence of venous thromboembolism verified by necropsy over 30 years. BMJ. 1991;302(6778):709–771.
3.
PrandoniPPolistenaPBernardiE. Upper-extremity deep vein thrombosis: risk factors, diagnosis, and complications. Arch Intern Med. 1997;157(1):57–62.
4.
HeitJAO’FallonWMPettersonTM. Relative impact of risk factors for deep vein thrombosis and pulmonary embolism: a population-based study. Arch Intern Med. 2002;162(11):1245–1248.
5.
GolinVSprovieriSRBedrikowRSallesMJ. Pulmonary thromboembolism: retrospective study of necropsies performed over 24 years in a university hospital in Brazil. Sao Paulo Med J. 2002;120(4):105–108.
6.
ClagettGPReischJS. Prevention of venous thromboembolism in general surgical patients. Results of meta-analysis. Ann Surg. 1988;208(2):227–240.
7.
KearonCJulianJANewmanTEGinsbergJS. Noninvasive diagnosis of deep venous thrombosis. McMaster Diagnostic Imaging Practice Guidelines Initiative. Ann Intern Med. 1998;128(8):663–677.
8.
WellsPSHirshJAndersonDR. Accuracy of clinical assessment of deep-vein thrombosis. Lancet. 1995;345(8961):1326–1330.
9.
RilesFRLevineMN. Epidemiology of thrombosis in cancer. Acta Haematol. 2001;106(1-2):6–12.
10.
WakefieldTWMcLaffertyRBLohrJMCapriniJAGillespieDLPassmanMA; Executive Committee of the American Venous Forum. Call to action to prevent venous thromboembolism. J Vasc Surg. 2009;49(6):1620–1623.
11.
BarbarSNoventaVRossettoAFerrariB. A risk assessment model for the identification of hospitalized medical patients at risk for venous thromboembolism: the Padua Prediction Score. J Thromb Haemostas. 2010;8(11):2450–2457.
12.
WickiJPerrierAPernegerTVBounameauxHJunodAF. Predicting adverse outcome in patients with acute pulmonary embolism: a risk score. Thromb Haemost. 2000;84(4):548–552.
13.
WellsPSAndersonDRBormanisJ. Value of assessment of pretest probability of deep-vein thrombosis in clinical management. Lancet. 1997;350(9094):1795–1798.
14.
CohenATDavidsonBLGallusAS; ARTEMIS Investigators. Efficacy and safety of fondaparinux for the prevention of venous thromboembolism in older acute medical patients: randomised placebo controlled trial. BMJ. 2006;332(7537):325–329.
15.
La TorreG.Applied Epidemiology and Biostatistics. Torino, Italy: SEEd srl; 2010. ISBN 978-88-8968-856-4.
16.
TapsonVFDecoususHPiniM; IMPROVE Investigators. Venous thromboembolism prophylaxis in acutely ill hospitalized medical patients: findings from the International Medical Prevention Registry on Venous Thromboembolism. Chest. 2007;132(3):936–945.
17.
CohenATAlikhanRArcelusJI. Assessment of venous thromboembolism risk and the benefits of thromboprophylaxis in medical patients. Thromb Haemost. 2005;94(4):750–759.
18.
CohenATAgnelliGAndersonFA; VTE Impact Assessment Group in Europe (VITAE). Venous thromboembolism (VTE) in Europe. The number of VTE events and associated morbidity and mortality. Thromb Haemost. 2007;98(4):756–764.
19.
HeitJAMeltonLJIIILohseCM. Incidence of venous thromboembolism in hospitalized patients vs community residents. Mayo Clin Proc. 2001;76(11):1102–1110.
20.
SamamaMMCohenATDarmonJY. A comparison of enoxaparin with placebo for the prevention of venous thromboembolism in acutely ill medical patients. N Engl J Med. 1999;34(11):793–800.
21.
BraekkanSKMathiesenEBNjølstadIWilsgaardTHansenJB. Hematocrit and risk of venous thromboembolism in a general population. The Tromso Study. Haematologica. 2010;95(2):270–275.
22.
EischerLTscholVHeinzeGTrabyLKyrlePAEichingerS. Hematocrit and the risk of recurrent venous thrombosis: a prospective cohort study. PLoS One. 2012;7(6):e38705.
23.
van MontfoortMLStephanFLauwMN. Circulating nucleosomes and neutrophil activation as risk factors for deep vein thrombosis. Arterioscler Thromb Vasc Biol. 2013;33(1):147–151.
24.
GerardAPShahniwazBBhagatTKimJChendrasekharA. Systemic inflammatory response syndrome and platelet count ≥250×10(9) are associated with venous thromboembolic disease. Int J Gen Med. 2015;8:37–40.
25.
LibraMMalaponteGPoleselJ. IL-6-174 G>C and MMP-9-1562 C>T polymorphisms are associated with increased risk of deep vein thrombosis in cancer patients. Cytokine. 2013;62(1):64–69.
26.
FuchsTABrillAWagnerDD. Neutrophil extracellular trap (NET) impact on deep vein thrombosis. Arterioscler Thromb Vasc Biol. 2012;32(8):1777–1783.
27.
VieiraLMDusseLHFernandesAP. Monocyte and plasma tissue factors in normal individuals and patients with deep venous thrombosis of the lower limbs. Thromb Res. 2007;119(2):157–165.
28.
BakirciEMTopcuSKalkanK. The role of the nonspecific inflammatory markers in determining the anatomic extent of venous thromboembolism. Clin Appl Thromb Hemost. 2015;21(2):181–185.
29.
AgenoWAgnelliGImbertiD; MASTER Investigators. Factors associated with the timing of diagnosis of venous thromboembolism: results from the MASTER registry. Thromb Res. 2008;121(6):751–756.
30.
AgnelliGVersoMAgenoW; MASTER Investigators. The MASTER registry on venous thromboembolism: description of the study cohort. Thromb Res. 2008;121(5):605–610.
31.
SignorelliSSFioreVPucciaGMastrosimoneGAnzaldiM. Thrombophilia in patients with lower limb deep veins thrombosis (LDVT) results of a monocentric survey on 103 consecutive outpatients. Clin Appl Thromb Hemost. 2014;20(6):589–593.
