Many recent studies have suggested that psoriasis, a chronic, inflammatory, immune-mediated skin disease, is associated with increased risk of cardiovascular disease (CVD). We aimed to compare arterial stiffness in psoriasis and control patient groups using the cardio-ankle vascular index (CAVI) and to determine whether psoriasis is an independent risk factor for CVD. A total 103 patients with psoriasis and 103 age- and sex-matched controls were enrolled. Compared with controls, the patients showed a higher CAVI (P = .03), particularly patients older than 40 years. The duration of psoriasis exhibited a positive correlative tendency with CAVI (P = .066). Moreover, psoriasis is an independent predictor of arterial stiffness after adjusting for other factors (P = .011). We suggest that psoriasis can be a risk factor for CVD, and older patients with psoriasis of longer disease duration should be monitored carefully for cardiovascular risk.
GriffithsCEBarkerJN. Pathogenesis and clinical features of psoriasis. Lancet. 2007;370(9583):263–271.
2.
TortiDCFeldmanSR. Interleukin-12, interleukin-23, and psoriasis: current prospects. J Am Acad Dermatol. 2007;57(6):1059–1068.
3.
GrozdevIKormanNTsankovN. Psoriasis as a systemic disease. Clin Dermatol. 2014;32(3):343–350.
4.
LowesMAKikuchiTFuentes-DuculanJ. Psoriasis vulgaris lesions contain discrete populations of Th1 and Th17 T cells. J Invest Dermatol. 2008;128(5):1207–1211.
5.
ChristophersEMetzlerGRockenM. Bimodal immune activation in psoriasis. Br J Dermatol. 2014;170(1):59–65.
6.
BaltaIBaltaSDemirkolS. Elevated serum levels of endocan in patients with psoriasis vulgaris: correlations with cardiovascular risk and activity of disease. Br J Dermatol. 2013;169(5):1066–1070.
7.
RobatiRMPartovi-KiaMHaghighatkhahHRYounespourSAbdollahimajdF. Increased serum leptin and resistin levels and increased carotid intima-media wall thickness in patients with psoriasis: is psoriasis associated with atherosclerosis?J Am Acad Dermatol. 2014;71(4):642–648.
8.
WrightCIBrouwer-de CockKAKronerCIHoeksAPDraijerR. The relation of arterial stiffness to endothelial function in healthy subjects. Physiol Meas. 2007;28(5):573–582.
9.
AltunBBulucuFDemirbasS. The relationship between some of the cardiovascular risk factors and arterial stiffness parameters in essentially hypertensive patients. Clin Exp Hypertens. 2013;35(6):444–448.
10.
TakakiAOgawaHWakeyamaT. Cardio-ankle vascular index is superior to brachial-ankle pulse wave velocity as an index of arterial stiffness. Hypertens Res. 2008;31(7):1347–1355.
11.
SunCK. Cardio-ankle vascular index (CAVI) as an indicator of arterial stiffness. Integr Blood Press Control. 2013;6:27–38.
12.
ShiraiKUtinoJOtsukaKTakataM. A novel blood pressure-independent arterial wall stiffness parameter; cardio-ankle vascular index (CAVI). J Atheroscler Thromb. 2006;13(2):101–107.
13.
ShiraiKSaikiANagayamaDTatsunoIShimizuKTakahashiM. The Role of Monitoring Arterial Stiffness with Cardio-Ankle Vascular Index in the Control of Lifestyle-Related Diseases. Pulse (Basel). 2015;3(2):118–133.
14.
Shiva KumarPMedina-LezamaJMorey-VargasO; PREVENCION Investigators. Prospective risk factors for increased central augmentation index in men and women. Am J Hypertens. 2015;28(1):121–126.
15.
GelfandJMNeimannALShinDBWangXMargolisDJTroxelAB. Risk of myocardial infarction in patients with psoriasis. JAMA. 2006;296(14):1735–1741.
16.
AhlehoffOGislasonGHCharlotM. Psoriasis is associated with clinically significant cardiovascular risk: a Danish nationwide cohort study. J Intern Med. 2011;270(2):147–157.
LauEOTseHFChanRH. Prediction of aortic augmentation index using radial pulse transmission-wave analysis. J Hypertens. 2006;24(4):723–730.
19.
StonerLFaulknerJLoweA. Should the augmentation index be normalized to heart rate?J Atheroscler Thromb. 2014;21(1):11–16.
20.
McEnieryCMWallaceSMackenzieIS. Endothelial function is associated with pulse pressure, pulse wave velocity, and augmentation index in healthy humans. Hypertension. 2006;48(4):602–608.
21.
EvensenKSlevoldenESkagenK. Increased subclinical atherosclerosis in patients with chronic plaque psoriasis. Atherosclerosis. 2014;237(2):499–503.
22.
KimSYYangHSLeeYWChoeYBAhnKJ. Evaluation of the Beta Stiffness Index and Carotid Intima-Media Thickness in Asian Patients With Psoriasis. Angiology. 2015;66(9):889–895.
23.
YiuKHYeungCKChanHT. Increased arterial stiffness in patients with psoriasis is associated with active systemic inflammation. Br J Dermatol. 2011;164(3):514–520.
24.
HanssonGK. Inflammation, atherosclerosis, and coronary artery disease. N Engl J Med. 2005;352(16):1685–1695.
25.
MehtaNNYuYPinnelasR. Attributable risk estimate of severe psoriasis on major cardiovascular events. Am J Med. 2011;124(8):775. e771-e776.
26.
SettyARCurhanGChoiHK. Obesity, waist circumference, weight change, and the risk of psoriasis in women: Nurses’ Health Study II. Arch Intern Med. 2007;167(15):1670–1675.
27.
JensenPZachariaeCChristensenR. Effect of weight loss on the cardiovascular risk profile of obese patients with psoriasis. Acta Derm Venereol. 2014;94(6):691–694.
28.
NaldiLContiACazzanigaS; Psoriasis Emilia Romagna Study Group. Diet and physical exercise in psoriasis: a randomized controlled trial. Br J Dermatol. 2014;170(3):634–642.
29.
KimCRLeeJH. An observational study on the obesity and metabolic status of psoriasis patients. Ann Dermatol. 2013;25(4):440–444.
