Serum Omentin 1 Level Is Associated With Coronary Artery Disease and Its Severity in Postmenopausal Women

Abstract

We evaluated whether serum omentin levels are associated with coronary artery disease (CAD) and its severity among postmenopausal women. We enrolled 193 consecutive postmenopausal women who had undergone coronary angiography for suspected stable CAD. The study population was divided into 2 groups based on the results of coronary angiography (CAD group, n = 110 and control group, n = 83). Omentin 1 levels were measured and disease severity was assessed using the SYNTAX score (SS) in the CAD group. Those patients with angiographic CAD had significantly decreased omentin 1 levels, compared to those without CAD (247.5 + 127.4 vs 506 + 246 ng/mL, P < .001). After adjusting for cardiovascular risk factors, a decreased omentin 1 level was found to be an independent predictor of both angiographic CAD and a high SS. Our data indicate that a decreased omentin 1 level is associated with CAD and its severity among postmenopausal women.

Keywords

omentin 1 adipose tissue syntax score coronary artery disease inflammation postmenopausal women

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References

American Heart Association. Heart Disease and Stroke Statistics—2010 Update. A Report of the American Heart Association. Dallas, TX: Author; 2010; 121:46–215.

Arslanian-Engoren

. Women’s risk factors and screening for coronary heart disease. J Obstet Gynecol Neonatal Nurs. 2011;40(3):337–346.

Wang

Nakayama

. Inflammation, a link between obesity and cardiovascular disease. Mediators Inflamm. 2010;2010:535918.

Pan

H-Y

Guo

. Changes of serum omentin-1 levels in normal subjects and in patients with impaired glucose regulation and with newly diagnosed and untreated type 2 diabetes. Diabetes Res Clin Pract. 2010;88(1):29–33.

de Souza Batista

Yang

Lee

. Omentin plasma levels and gene expression are decreased in obesity. Diabetes. 2007;56(6):1655–1661.

Wurm

Neumeier

Weigert

Schaffler

Buechler

. Plasma levels of leptin, omentin, collagenous repeat-containing sequence of 26-kDa protein (CORS-26) and adiponectin before and after oral glucose uptake in slim adults. Cardiovasc Diabetol. 2007;6(1):7.

El-Mesallamy

El-Derany

Hamdy

. Serum omentin-1 and chemerin levels are interrelated in patients with type 2 diabetes mellitus with or without ischaemic heart disease. Diabet Med. 2011;28(10):1194–200.

Yoo

Hwang

Hong

. Association of circulating omentin-1 level with arterial stiffness and carotid plaque in type 2 diabetes. Cardiovasc Diabetol. 2011;10:103.

Shibata

Ouchi

Kikuchi

. Circulating omentin is associated with coronary artery disease in men. Atherosclerosis. 2011;219(2):811–814.

10.

Serruys

Onuma

Garg

. Assessment of the SYNTAX score in the syntax study. Eurointervention. 2009;5(1):50–56.

11.

Attie

Scherer

. Adipocyte metabolism and obesity. J Lipid Res. 2009;50 suppl:S395–S399.

12.

De Clercq

Taylor

Zahradka

. Adipose tissue: the link between obesity and cardiovascular disease. Cardiovasc Hematol Disord Drug Targets. 2008;8(3):228–237.

13.

Rajala

Scherer

. Minireview: the adipocyte at the crossroads of energy homeostasis, inflammation, and atherosclerosis. Endocrinology. 2003;144(9):3765–3773.

14.

Zhou

Chan

Zhou

. Omentin: linking metabolic syndrome and cardiovascular disease [published online June 22, 2012]. Curr Vasc Pharmacol. 2012.

15.

Sahin

Akpek

Elcik

. Bilirubin levels and the burden of coronary atherosclerosis in patients with STEMI. Angiology. 2013;64(3):200–204.

16.

Yang

R-Z

Lee

M-J

. Identification of omentin as a novel depot-specific adipokine in human adipose tissue: possible role in modulating insulin action. Am J Physiol Endocrinol Metab. 2006;290(6):1253–1261.

17.

Schäffler

Zeitoun

Wobser

Buechler

Aslanidis

Herfarth

. Frequency and significance of the novel single nucleotide missense polymorphism Val109Asp in the human gene encoding omentin in caucasian patients with type 2 diabetes mellitus or chronic inflammatory bowel diseases. Cardiovasc Diabetol. 2007;6:3.

18.

Senolt

Polanská

Filková

. Vaspin and omentin: new adipokines differentially regulated at the site of inflammation in rheumatoid arthritis. Ann Rheum Dis. 2010;69(7):1410–1411.

19.

Yamawaki

Kuramoto

Kameshima

Usui

Okada

Hara

. Omentin, a novel adipocytokine inhibits TNF-induced vascular inflammation in human endothelial cells. Biochem Biophys Res Commun. 2011;408(2):339–343.