Prothrombotic diathesis expressed by elevated levels of coagulation-specific biomarkers has been reported in patients with abdominal aortic aneurysm (AAA) and after AAA endovascular repair (EVAR). This study investigates the effect of antiplatelet agents (APLs) on the prothrombotic diathesis in the post-EVAR period. Forty elective EVAR patients had thrombin–antithrombin complex, d-dimer, fibrinopeptide A, and high-sensitivity C-reactive protein measured before, at 24 hours, 1 month, and 6 months after EVAR. Patients receiving APLs postoperatively were compared with those not receiving APLs. All biomarkers were above the normal limits preoperatively and increased significantly 24 hours postoperatively followed by a drop at 1 and 6 months. No statistically significant changes were noted among patients receiving APLs in comparison with those not receiving APLs. The preoperative and postoperative prothrombotic diathesis of AAA following EVAR was confirmed in line with other reports. There was however no significant alteration of the examined biomarkers in patients receiving APLs.
DaviesRSAbdelhamidMWallMLVohraRKBradburyAWAdamDJ. Coagulation, fibrinolysis, and platelet activation in patients undergoing open and endovascular repair of abdominal aortic aneurysm. J Vasc Surg. 2011;54(3):865–878.
2.
HolmbergABergqvistDSiegbahnA. Coagulation and fibrinolysis after open infrarenal abdominal aortic aneurysm repair in a long-term perspective. Thromb Res. 1999;96(2):99–105.
3.
ParryDJAl-BarjasHSChappellLRashidTAriënsRAScottDJ. Haemostatic and fibrinolytic factors in men with a small abdominal aortic aneurysm. Br J Surg. 2009;96(8):870–877.
4.
EnglbergerLSavolainenHJandusP. Activated coagulation during open and endovascular abdominal aortic aneurysm repair. J Vasc Surg. 2006;43(6):1124–1129.
5.
DaviesRSMAbdelhamidMVohraRKBradburyAWAdamDJ. The relationship between aortic aneurysm sac thrombus volume on coagulation, fibrinolysis and platelet activity. Thromb Res. 2012;130(3):463–466.
6.
AdamDJLudlamCARuckleyCVBradburyAW. Coagulation and fibrinolysis in patients undergoing operation for ruptured and nonruptured infrarenal abdominal aortic aneurysms. J Vasc Surg. 1999;30(4):641–650.
7.
CrossKSBouchier-HayesDLeahyAL. Consumptive coagulopathy following endovascular stent repair of abdominal aortic aneurysm. Eur J Vasc Endovasc Surg. 2000;19(1):94–95.
8.
AbdelhamidMFDaviesRSAdamDJVohraRKBradburyAW. Changes in thrombin generation, fibrinolysis, platelet and endothelial cell activity, and inflammation following endovascular abdominal aortic aneurysm repair. J Vasc Surg. 2012;55(1):41–46.
9.
WallinderJBergqvistDHenrikssonAE. Haemostatic markers in patients with abdominal aortic aneurysm and the impact of aneurysm size. Thromb Res. 2009;124(4):423–426.
10.
YamazumiKOjiroMOkumuraHAikouT. An activated state of blood coagulation and fibrinolysis in patients with abdominal aortic aneurysm. Am J Surg. 1998;175(4):297–301.
11.
IharaAKawamotoTMatsumotoK. Relationship between hemostatic markers and circulating biochemical markers of collagen metabolism in patients with aortic aneurysm. Pathophysiol Haemost Thromb2003;33(4):221–224.
12.
MonacoMDi TommasoLStassanoP. Impact of blood coagulation and fibrinolytic system changes on early and mid term clinical outcome in patients undergoing stent endografting surgery. Interact Cardiovasc Thorac Surg. 2006;5(6):724–728.
13.
AbdelhamidMFDaviesRSMVohraRKAdamDJBradburyAW. Effect of endovascular and open abdominal aortic aneurysm repair on thrombin generation and fibrinolysis. J Vasc Surg. 2013;57(1):103–107.
14.
SwartbolPNorgrenLAlbrechtssonUCwikielWJahrJJonungT. Biological responses differ considerably between endovascular and conventional aortic aneurysm surgery. Eur J Vasc Endovasc Surg. 1996;12(1):18–25.
15.
BaileyMAGriffinKJSohrabiS. Plasma thrombin-antithrombin complex, prothrombin fragments 1 and 2, and D-dimer levels are elevated after endovascular but not open repair of infrarenal abdominal aortic aneurysm. J Vasc Surg. 2013;57(6):1512–1518.
16.
DaviesRSAbdelhamidMVohraRKBradburyAWAdamDJ. Perioperative myocardial injury and hemostasis in patients undergoing endovascular aneurysm repair for asymptomatic infrarenal abdominal aortic aneurysm. Vasc Endovascular Surg. 2011;45(8):712–716.
17.
AokiASuezawaTSangawaKTagoM. Effect of type II endoleaks and antiplatelet therapy on abdominal aortic aneurysm shrinkage after endovascular repair. J Vasc Surg. 2011;54(4):947–951.
18.
AlmquistTJacobsonSHLinsPEFarndaleRWHjemdahlP. Effects of lipid-lowering treatment on platelet reactivity and platelet-leukocyte aggregation in diabetic patients without and with chronic kidney disease: a randomized trial. Nephrol Dial Transplant. 2012;27(9):3540–3546.
19.
ParaskevasKILiapisCDHamiltonGMikhailidisDP. Can statins reduce perioperative morbidity and mortality in patients undergoing non-cardiac vascular surgery?Eur J Vasc Endovasc Surg. 2006;32(3):286–293.
20.
ParaskevasKIVeithFJLiapisCDMikhailidisDP. Perioperative/periprocedural effects of statin treatment for patients undergoing vascular surgery or endovascular procedures: an update. Curr Vasc Pharmacol. 2013;11(1):112–120.
21.
VioliFCalvieriCFerroDPignatelliP. Statins as antithrombotic drugs. Circulation. 2013;127(2):251–257.
22.
KatsikiNPapadopoulouSKFachantidouAIMikhailidisDP. Smoking and vascular risk: are all forms of smoking harmful to all types of vascular disease?Public Health. 2013;127(5):435–441.
23.
CarrMEDiabetes mellitus: a hypercoagulable state. J Diabetes Complications. 2001;15(1):44–54.
24.
KaragiannisATziomalosKAnagnostisP. The effect of antihypertensive agents on insulin sensitivity, lipids and haemostasis. Curr Vasc Pharmacol. 2010;8(6):792–803.
25.
SaganAMrowieckiWMikolajczykT. Local inflammation is associated with aortic thrombus formation in abdominal aortic aneurysms. relationship to clinical risk factors. Thromb Haemost. 2012;108(5):812–823.
26.
SilvainJColletJPNagaswamiC. Composition of coronary thrombus in acute myocardial infarction. J Am Coll Cardiol. 2011;57(12):1359–1367.
27.
AdolphRVorpDASteedDLWebsterMWKamenevaMVWatkinsSC. Cellular content and permeability of intraluminal thrombus in abdominal aortic aneurysm. J Vasc Surg. 1997;25(5):916–926.
28.
GerasimidisTSfyroerasGTrellopoulosG. Impact of endograft material on the inflammatory response after elective endovascular AAA repair. Angiology. 2005;56(6):743–753.
29.
MollFLPowellJTFraedrichG. Management of abdominal aortic aneurysms clinical practice guidelines of the European society for vascular surgery. Eur J Vasc Endovas Surg. 2011;41(suppl 1):S1–S58
