Carbon monoxide (CO) poisoning is frequent and can lead to high morbidity and mortality. Some studies have indicated increased platelet activation and aggregation in CO poisoning. Thus, we investigated mean platelet volume (MPV), an indicator of platelet activation, in patients with CO poisoning. We included 193 (117 women) patients who presented with a diagnosis of CO poisoning between June 2011 and March 2013. Control group was composed of 39 (15 women) patients. Troponin and creatine kinase MB levels were significantly higher in the CO poisoning group. Platelet counts were significantly higher in patients with CO poisoning (281 ± 76 vs 248 ± 65 × 109, respectively; P = .01). Similarly, MPV was significantly higher in the CO poisoning group (8.9 ± 0.8 vs 7.9 ± 0.9 fL, respectively; P < .001). Elevated MPV values may indicate that patients with CO poisoning have a higher risk of thromboembolic and cardiovascular complications due to platelet activation.
WeaverLK.Clinical practice. Carbon monoxide poisoning. N Engl J Med. 2009;360(12):1217–1225.
4.
GeringSAFoltsJD. Exacerbation of acute platelet thrombus formation in stenosed dog coronary arteries with smoke from a non-tobacco burning cigarette. J Lab Clin Med. 1990;116(5):728–736.
5.
BierenbaumMLFleischmanAIStierASomolHWatsonPB. Effect of cigarette smoking upon in vivo platelet function in man. Thromb Res. 1978;12(6):1051–1057.
6.
GraceTWPlattFW. Subacute carbon monoxide poisoning. Another great imitator. JAMA. 1981;246(15):1698–1700.
7.
AronowWS. Effect of carbon monoxide on cardiovascular disease. Prev Med. 1979;8(3):271–278.
8.
VarolEOzaydinMAslanSMDoğanAAltinbaşA. A rare cause of myocardial infarction: acute carbon monoxide poisoning. Anadolu Kardiyol Derg. 2007;7(3):322–323.
9.
HsuPCLinTHSuHM. Acute carbon monoxide poisoning resulting in ST elevation myocardial infarction: a rare case report. Kaohsiung J Med Sci. 2010;26(5):271–275.
10.
ParkYSchoeneNHarrisW. Mean platelet volume is an indicator of platelet activation: methodological issues. Platelets. 2002;13(5-6):301–306.
11.
MartinJFTrowbridgeEASalmonGLPlumbJ. The biological significance of platelet volume: its relationship to bleeding time, platelet thromboxane B2 production and megakaryocyte nuclear DNA concentration. Thromb Res. 1983;32(5):443–460.
12.
JakubowskiJAThompsonCBVaillancourtRValeriCRDeykinD. Arachidonic acid metabolism by platelets of differing size. Br J Haematol. 1983;53(3):503–511.
13.
GilesHSmithREMartinJF. Platelet glycoprotein IIb-IIIa and size are increased in acute myocardial infarction. Eur J Clin Invest. 1994;24(1):69–72.
14.
JagroopIAClatworthyILewinJMikhailidisDP. Shape change in human platelets: measurement with a channelyzer and visualisation by electron microscopy. Platelets. 2000;11(1):28–32.
15.
GasparyanAYAyvazyanLMikhailidisDPKitasGD. Mean platelet volume: a link between thrombosis and inflammation?Curr Pharm Des. 2011;17(1):47–58.
AlonsoJRCardellachFLópezSCasademontJMiróO. Carbon monoxide specifically inhibits cytochrome c oxidase of human mitochondrial respiratory chain. Pharmacol Toxicol. 2003;93(3):142–146.
18.
ErnstAZibrakJD. Carbon monoxide poisoning. N Engl J Med. 1998;339(22):1603–1608.
19.
OlsonKR. Carbon monoxide poisoning: mechanisms, presentation, and controversies in management. J Emerg Med. 1984;1(3):233–243.
20.
ChoiIS. Carbon monoxide poisoning: systemic manifestations and complications. J Kor Med Sci. 2001;16(3):253–261.
21.
Marius-NunezAL. Myocardial infarction with normal coronary arteries after acute exposure to carbon monoxide. Chest. 1990;97(2):491–494.
22.
Ruth-SahdLAZulkoskyKFetterME. Carbon monoxide poisoning: case studies and review. Dimens Crit Care Nurs. 2011;30(6):303–314.
23.
FelnerJMChurchwellALMurphyDA. Right atrial thromboemboli: clinical, echocardiographic and pathophysiologic manifestations. J Am Coll Cardiol. 1984;4(5):1041–1051.
24.
YildirimCGunayNBuyukaslanHKucukdurmazZBozkurtS. A case of carbon monoxide poisoning with thrombus in the heart: a case report. Inhal Toxicol. 2005;17(14):797–801.
25.
LeeSJKangJHKimNY. A case report of carbon monoxide poisoning induced cardiomyopathy complicated with left ventricular thrombus. J Cardiovasc Ultrasound. 2011;19(2):83–86.
26.
TucciaroneMArizaca-DileoPRodriguez-CastroEGuerreroM. Myocardial infarction secondary to carbon monoxide poisoning: an uncommon presentation of a common condition. Case report and review of the literature. Am J Ther. 2009;16(5):462–465.
27.
VijAG. Effect of prolonged stay at high altitude on platelet aggregation and fibrinogen levels. Platelets. 2009;20(6):421–427.
28.
SatranDHenryCRAdkinsonCNicholsonCIBrachaYHenryTD. Cardiovascular manifestations of moderate to severe carbon monoxide poisoning. J Am Coll Cardiol. 2005;45(9):1513–1516.
29.
AslanSErolMKKarciogluOMeralMCakirZKatirciY. The investigation of ischemic myocardial damage in patients with carbon monoxide poisoning [in Turkish]. Anadolu Kardiyol Derg. 2005;5(3):189–193.
30.
BoosCJLipGY. Assessment of mean platelet volume in coronary artery disease: what does it mean?Thromb Res. 2007;120(1):11–13.
