Sage Journals: Discover world-class research

Abstract

Most patients with peripheral arterial disease (PAD) are asymptomatic and have similar vascular morbidity and mortality with patients with symptomatic PAD. Despite being a very highly prevalent disease, physicians underdiagnose and undertreat PAD. A total of 100 participants with aortic valve sclerosis (AVS) and 100 participants without AVS and age-, gender-, and cardiovascular risk factor–matched participants were enrolled. Ankle–brachial index (ABI) and AVS were evaluated by handheld Doppler device and echocardiography, respectively. There was significantly lower ABI in participants with AVS compared with those without AVS (1.04 ± 0.14 v 1.11 ± 0.07, P = .001). There was a negative correlation between ABI and AVS (r = −.29, P < .001). Linear regression analysis demonstrated an independent association between ABI and AVS (95% confidence interval [CI]: −0.91 to −0.27, P < .001) and β-blocker use (95% CI: −0.96 to −0.02, P: .04). Our findings confirm an association between AVS and PAD that may be attributed to shared vascular risk factors.

Keywords

ankle–brachial index aortic valve sclerosis peripheral arterial disease

Get full access to this article

View all access options for this article.

References

Criqui

Langer

Fronek

. Mortality over a period of 10 years in patients with peripheral arterial disease. N Engl J Med. 1992;326(6):381–386.

Hirsch

Criqui

Treat-Jacobson

. Peripheral arterial disease detection, awareness, and treatment in primary care. JAMA. 2001;286(11):1317–1324.

Welten

Schouten

Hoeks

. Long-term prognosis of patients with peripheral arterial disease: a comparison in patient with coronary artery disease. J Am Coll Cardiol. 2008;51(16):1588–1596.

Diehm

Allenberg

Pittrow

. German epidemiological trial on ankle brachial index study group. Mortality and vascular morbidity in older adults with asymptomatic versus symptomatic peripheral artery disease. Circulation. 2009;120(21):2053–2061.

Selvin

Erlinger

. Prevalence of and risk factors for peripheral arterial disease in the United States: results from the national health and nutrition examination survey, 1999-2000. Circulation. 2004;110(6):738–743.

Belch

JJF

Topol

Agnelli

. Critical issues in peripheral arterial disease detection and management: a call to action. Arch Intern Med. 2003;163(8):884–892.

Ferket

Spronk

Colkesen

Hunink

. Systematic review of guidelines on peripheral artery disease screening. Am J Med. 2012;125(2):198–208.

Agmon

Khandheria

Meissner

. Aortic valve sclerosis and aortic atherosclerosis: different manifestations of the same disease? Insights from a population based study. J Am Coll Cardiol. 2001;38(3):827–834.

Pohle

Maffert

Ropers

. Progression of aortic valve calcification: association with coronary atherosclerosis and cardiovascular risk factors. Circulation. 2001;104(16):1927–1932.

10.

Tziomalos

Athyros

Karagiannis

Mikhailidis

. Established and emerging vascular risk factors and the development of aortic stenosis: an opportunity for prevention? Expert Opin Ther Targets. 2008;12(7):809–820.

11.

Norgren

Hiatt

, Dormandy JA, et al. on behalf of the TASC II Working Group. Intersociety consensus for the management of peripheral arterial disease (TASC II). Eur J Vasc Endovasc Surg. 2007;33(6):S1–S75.

12.

Hyatt

. Medical treatment of peripheral arterial disease and claudication. N Engl J Med. 2001;344(21):1608–1621.

13.

Hirsch

Criqui

Treat-Jacobson

. Peripheral arterial disease detection, awareness, and treatment in primary care. JAMA. 2001;286(11):1317–1324.

14.

Leng

Lee

Fowkes

. Incidence, natural history and cardiovascular events in symptomatic and asymptomatic peripheral arterial disease in the general population. Int J Epidemiol. 1996;25(6):1172–1181.

15.

Feringa

Karagiannis

Schouten

. Prognostic significance of declining ankle-brachial index values in patients with suspected or known peripheral arterial disease. Eur J Vasc Endovasc Surg. 2007;34(2):206–213.

16.

Murabito

Evans

Nieto

. Prevalence and clinical correlates of peripheral arterial disease in the Framingham offspring study. Am Heart J. 2002;143(6):961–965.

17.

Blacher

Cacoub

Luizy

. Peripheral arterial disease vs other localizations of vascular disease: the ATTEST study. J Vasc Surg. 2006;44(2):314–318.

18.

Bergiers

Vaes

Degryse

. To screen or not to screen for peripheral arterial disease in subjects aged 80 and over in primary health care: a cross-sectional analysis from the BELFRAIL study. BMC Fam Pract. 2011;12:39.

19.

Taylor-Piliae

Fair

Varady

. Ankle brachial index screening in asymptomatic older adults. Am Heart J. 2011;161(5):979–985.

20.

Khan

Rahim

Anand

. Does the clinical examination predict lower extremity peripheral arterial disease? J Am Med Assoc. 2006;295(5):536–546.

21.

Freeman

Otto

. Spectrum of calcific aortic valve disease: pathogenesis, disease progression, and treatment strategies. Circulation. 2005;111(24):3316–3326.

Relation Between Aortic Valve Sclerosis and Ankle–Brachial Index in Participants Clinically Free of Atherosclerotic Vascular Disease

Abstract

Keywords

Get full access to this article

References