We investigated whether the mean platelet volume (MPV) is associated with the extent and complexity of coronary artery disease in patients with ST elevation myocardial infarction (STEMI). We prospectively included 912 STEMI patients (663 male and 249 female; mean age 58.7 ± 12.4 years) who underwent primary percutaneous coronary intervention. The patients were divided into 3 groups according to MPV tertiles. Highest SYNTAX score (SS) was observed in MPVhigh group compared with MPVmid and MPVlow groups (P < .001 for all). The SS of MPVmid group was higher than MPVlow group (P = .036). The MPV in diabetic STEMI patients was higher than in nondiabetic STEMI patients (P < .001). Multivariate linear regression analysis showed that the MPV was associated with diabetes (β = .115, P = .001), troponin level (β = .131, P = .001), platelet count (β = −.241, P < .001), and SS (β = .216, P < .001). The relation between MPV and SS in diabetic STEMI patients was stronger than for nondiabetic STEMI patients (r = .473, P < .001 vs r = .129, P = .001).
FrossardMFuchsILeitnerJM. Platelet function predicts myocardial damage in patients with acute myocardial infarction. Circulation. 2004;110(11):1392–1397.
2.
JagroopIAMikhailidisDP. Mean platelet volume is a useful parameter: a reproducible routine method using a modified Coulter Thrombocytometer. Platelets. 2001;12(3):171.
3.
MartinJFBathPMBurrML. Influence of platelet size on outcome after myocardial infarction. Lancet. 1991;338(8780):1409–1411.
4.
ChuSGBeckerRCBergerPB. Mean platelet volume as a predictor of cardiovascular risk: a systematic review and meta-analysis. J Thromb Haemost. 2010;8(1): 148–156.
5.
Estévez-LoureiroRSalgado-FernándezJMarzoa-RivasR. Mean platelet volume predicts patency of the infarct-related artery before mechanical reperfusion and short-term mortality in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention. Thromb Res. 2009;124(5):536–540.
6.
TekbasEKaraAFAriturkZ. Mean platelet volume in predicting short- and long-term morbidity and mortality in patients with or without ST-segment elevation myocardial infarction. Scand J Clin Lab Invest. 2011;71(7):613–619.
7.
MadenOKacmazFSelcukH. Relationship of admission hematological indexes with myocardial reperfusion abnormalities in acute ST segment elevation myocardial infarction patients treated with primary percutaneous coronary interventions. Can J Cardiol. 2009;25(6):e164–e168.
8.
HekimsoyZPayzinBOrnekTKandoğanG. Mean platelet volume in type 2 diabetic patients. J Diabetes Complications. 2004;18(3):173–176.
9.
Papanas NSymeonidisGMaltezosE. Mean platelet volume in patients with type 2 diabetes mellitus. Platelets. 2004;15(8):475–478.
10.
DemirtuncRDumanDBasarMBilgiMTeometeMGaripT. The relationship between glycemic control and platelet activity in type 2 diabetes mellitus. J Diabetes Complications. 2009;23(2):89–94.
11.
GasparyanAYAyvazyanLMikhailidisDPKitasGD.Mean platelet volume: a link between thrombosis and inflammation?Curr Pharm Des. 2011;17(1):47–58.
12.
SianosGMorelMAKappeteinAP. The SYNTAX Score: an angiographic tool grading the complexity of coronary artery disease. EuroIntervention. 2005;1(2):219–227.
13.
CapodannoDDi SalvoMECincottaGMianoMTamburinoCTamburinoC. Usefulness of the SYNTAX score for predicting clinical outcome after percutaneous coronary intervention of unprotected left main coronary artery disease. Circ Cardiovasc Interv. 2009;2(4):302–308.
14.
CapodannoDCapranzanoPDi SalvoME. Usefulness of SYNTAX score to select patients with left main coronary artery disease to be treated with coronary artery bypass graft. J Am Coll Cardiol Intv. 2009;2(8):731–738.
15.
ElbasanZGürMSahinDY. Association of mean platelet volume and pre- and postinterventional flow with infarct-related artery in st-segment elevation myocardial infarction. Angiology. 2012. doi:10.1177/0003319712455685.
16.
Myocardial infarction redefined: a consensus document of The Joint European Society of Cardiology/American College of Cardiology Committee for the redefinition of myocardial infarction. Eur Heart J. 2000;21(18):1502–1513.
17.
SchillerNBShahPMCrawfordM. Recommendations for quantitation of the left ventricle by two-dimensional echocardiography. American Society of Echocardiography Committee on Standards, Subcommittee on Quantitation of Two-Dimensional Echocardiograms. J Am Soc Echocardiogr. 1989;2(5):358–367.
18.
DaviGPatronoC. Platelet activation and atherothrombosis. N Engl J Med. 2007;357(24):2482–2494.
19.
VizioliLMuscariSMuscariA. The relationship of mean platelet volume with the risk and prognosis of cardiovascular diseases. Int J Clin Pract. 2009;63(10):1509–1515.
20.
van der LooBMartinJF. Megakaryocytes and platelets in vascular disease. Baillieres Clin Haematol. 1997;10(1):109–123.
21.
MathurARobinsonMSCottonJMartinJFErusalimskyJD. Platelet reactivity in acute coronary syndromes: evidence for differences in platelet behaviour between unstable angina and myocardial infarction. Thromb Haemost. 2001;85(6):989–994.
22.
PizzulliLYangAMartinJFLuderitzB.Changes in platelet size and count in unstable angina compared to stable angina or non-cardiac chest pain. Eur Heart J. 1998;19(1):80–84.
23.
YilmazMBCihanGGurayY. Role of mean platelet volume in triagging acute coronary syndromes. J Thromb Thrombolysis. 2008;26(1):49–54.
24.
CameronHAPhillipsRIbbotsonRMCarsonPH. Platelet size in myocardial infarction. Br Med J (Clin Res Ed). 1983;287(6390):449–451.
25.
Kilicli-CamurNDemirtunçRKonuralpCEskiserABasaranY.Could mean platelet volume be a predictive marker for acute myocardial infarction?Med Sci Monit. 2005;11(8):CR387–CR392.
26.
GludTSchmidtEBKristensenSDArnfredT.Platelet number and volume during myocardial infarction in relation to infarct size. Acta Med Scand. 1986;220(5):401–405.
27.
De LucaGSantagostinoMSeccoGG. Mean platelet volume and the extent of coronary artery disease: results from a large prospective study. Atherosclerosis. 2009;206(1):292–297.
28.
MuratSNDuranMKalayN. Relation between mean platelet volume and severity of atherosclerosis in patients with acute coronary syndromes. Angiology. 2012. doi:10.1177/0003319711436247.
29.
DoganAAksoyFIcliA. Mean platelet volume is associated with culprit lesion severity and cardiac events in acute coronary syndromes without ST elevation. Blood Coagul Fibrinolysis. 2012;23(4):324–330.
30.
OzkanBUysalOKDuranM. relationship between mean platelet volume and atherosclerosis in young patients with ST elevation myocardial infarction. Angiology. 2012. doi:10.1177/0003319712448834.
31.
MuscariADe PascalisSCenniA. Determinants of mean platelet volume (MPV) in an elderly population: relevance of body fat, blood glucose and ischaemic electrocardiographic changes. Thromb Haemost. 2008;99(6):1079–1084.
32.
MagroMNautaSTSimsekC. Usefulness of the SYNTAX score to predict “no reflow” in patients treated with primary percutaneous coronary intervention for ST-segment elevation myocardial infarction. Am J Cardiol. 2012;109(5):601–606.
33.
MartynCNMatthewsDMPopp-SnijdersCTuckerJEwingDJClarkeBF. Effects of sorbinil treatment on erythrocytes and platelets of persons with diabetes. Diabetes Care. 1986;9(1):36–39.
34.
TavilYSenNYaziciH. Coronary heart disease is associated with mean platelet volume in type 2 diabetic patients. Platelets. 2010;21(5):368–372.
35.
MikhailidisDPBarradasMAMierA. Platelet function in patients admitted with a diagnosis of myocardial infarction. Angiology. 1987;38(1):36–45.
36.
AvramakisGPapadimitrakiEPapakonstandinouD. Platelets and white blood cell subpopulations among patients with myocardial infarction and unstable angina. Platelets. 2007;18(1):16–23
37.
ThompsonCBJakubowskiJA. The pathophysiology and clinical relevance of platelet heterogeneity. Blood. 1988;72(1):1–8.
38.
ErhartSBeerJHReinhartWH. Influence of aspirin on platelet count and volume in humans. Acta Haematol.1999;101(3):140–144.
39.
CobanEAfacanB.The effect of rosuvastatin treatment on the mean platelet volume in patients with uncontrolled primary dyslipidemia with hypolipidemic diet treatment. Platelets. 2008;19(2):111–114.
