Association Between Telomere Length and C-Reactive Protein and the Development of Coronary Collateral Circulation in Patients with Coronary Artery Disease
Restricted accessOtherFirst published online August, 2011
Association Between Telomere Length and C-Reactive Protein and the Development of Coronary Collateral Circulation in Patients with Coronary Artery Disease
Background: Coronary collateral circulation is a stabilizer factor in myocardial ischemia. We attempted to establish a link between collateral circulation, C-reactive protein (CRP), and telomere shortening. Patients and Methods: A case-control study was performed in patients with (group A) and without (group B) coronary collaterals using coronariography. The patients were males, CRP levels and telomere length in circulating leucocytes were measured; Student t test and logistic regression were used to analyze the data. Results: The study included 40 patients aged 53.9 ± 7.0 years (20 per group). Group A exhibited lower CRP levels (2.76 ± 3.34 vs 4.04 ± 3.38; P = .004); whereas telomere length was shorter in group B (2.3 ± 6.9 kb vs 6.1 ± 5.9 kb; P < .0001). Conclusions: Collateral circulation was associated with telomere shortening and elevation of CRP levels.
Koerselman J. , Van der Graaf Y., De Jaegere PP, Grobbee DECoronary collaterals: an important and underexposed aspect of coronary artery disease. Circulation. 2003;107(19):2507-2511.
Conway EM, Collen D., Carmeliet P.Molecular mechanisms of blood vessel growth. Cardiovasc Res . 2001;49(3):507-521.
4.
Voleti B., Agrawal A.Statins and nitric oxide reduce C-reactive protein production while inflammatory conditions persist. Mol Immunol.2006;43(7):891-896.
5.
Yasojima K., Schwab C., McGeer EG, McGeer PLGeneration of C-reactive protein and complement components in atherosclerotic plaques. Am J Pathol. 2001;158(3):1039-1051.
6.
Torzewski M. , Rist C., Mortensen RF, et al. C-reactive protein in the arterial intima: role of C-reactive protein receptor-dependent monocyte recruitment in atherogenesis. Arterioscler Thromb Vasc Biol. 2000;20(9):2094-2099.
7.
Wang CH, Li SH, Weisel RD, et al. C-reactive protein upregulates angiotensin type 1 receptors in vascular smooth muscle. Circulation. 2003 ;107(13):1783-1790.
8.
McEwen JE , Zimniak P., Mehta JL, Shmookler RJMolecular pathology of aging and its implications for senescent coronary atherosclerosis. Curr Opin Cardiol . 2005;20(5):399-406.
9.
Benetos A., Gardner JP, Zureik M., et al. Short telomeres are associated with increased carotid atherosclerosis in hypertensive subjects. Hypertension. 2004 ;43(2):182-185.
10.
Ogami M., Ikura Y., Ohsawa M., et al. Telomere shortening in human coronary artery diseases. Arterioscler Thromb Vasc Biol. 2004;24(3):546-550.
11.
Minamino T., Miyauchi H., Yoshida T., Ishida Y., Yoshida H., Komuro I.Endothelial cell senescence in human atherosclerosis: role of telomere in endothelial dysfunction. Circulation. 2002 ; 105(13):1541-1544.
12.
Scanlon PJ, Faxon DP, Audet AM, et al. ACC/AHA guidelines for coronary angiography: executive summary and recommendations. A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee on Coronary Angiography) developed in collaboration with the Society for Cardiac Angiography and Interventions. Circulation. 1999;99(17):2345-2357.
13.
Judkins MPSelective coronary arteriography. I. A percutaneous transfemoral technic. Radiology. 1967;89(5):815-824.
14.
Rentrop KP, Cohen M., Blanke H., Phillips RAChanges in collateral channel filling immediately after controlled coronary artery occlusion by an angioplasty balloon in human subjects. J Am Coll Cardiol. 1985;5(3):587-592.
15.
Cawthon RMTelomere measurement by quantitative PCR. Nucleic Acids Res.2002;30(10):e47.
16.
Nabata A., Kuroki M., Ueba H., et al. C-reactive protein induces endothelial cell apoptosis and matrix metalloproteinase-9 production in human mononuclear cells: Implications for the destabilization of atherosclerotic plaque. Atherosclerosis . 2008; 196(1):129-135.
17.
Stein MP, Edberg JC, Kimberly RP, et al. C-reactive protein binding to FcgammaRIIa on human monocytes and neutrophils is allele-specific. J Clin Invest. 2000;105(3):369-376.
18.
Danenberg HD , Szalai AJ, Swaminathan RV, et al. Increased thrombosis after arterial injury in human C-reactive protein-transgenic mice. Circulation . 2003;108(5):512-515.
19.
Wong M., Toh L., Wilson A., et al. Reduced arterial elasticity in rheumatoid arthritis and the relationship to vascular disease risk factors and inflammation. Arthritis Rheum. 2003;48(1):81-89.
20.
Kerner A., Gruberg L., Goldberg A., et al. Relation of C-reactive protein to coronary collaterals in patients with stable angina pectoris and coronary artery disease. Am J Cardiol. 2007;99(4):509-512.
21.
Blake GJ, Ridker PMC-reactive protein: a surrogate risk marker or mediator of atherothrombosis?Am J Physiol Regul Integr Comp Physiol. 2003 ;285(5):R1250-R1252.
22.
Yasojima K. , Schwab C., McGeer EG, McGeer PLGeneration of C-reactive protein and complement components in atherosclerotic plaques. Am J Pathol. 2001;158(3):1039-1051.
23.
Gilson E., Londoño-Vallejo A.Telomere length profiles in humans: all ends are not equal. Cell Cycle. 2007;6(20): 2486-2494.
24.
Vasan RS, Demissie S., Kimura M., et al. Association of leukocyte telomere length with echocardiographic left ventricular mass: the Framingham heart study. Circulation . 2009 September 29; 120(13):1195-202.
25.
Chamuleau SA , Vrijsen KR, Rokosh DG, Tang XL, Piek JJ, Bolli R.Cell therapy for ischaemic heart disease: focus on the role of resident cardiac stem cells. Neth Heart J.2009 May;17(5):199-207.
26.
Franco S., Segura I., Riese HH, Blasco MADecreased B16F10 melanoma growth and impaired vascularization in telomerase-deficient mice with critically short telomeres. Cancer Res. 2002;62(2):552-559.
27.
Pallini R., Pierconti F., Falchetti ML, et al. Evidence for telomerase involvement in the angiogenesis of astrocytic tumors: expression of human telomerase reverse transcriptase messenger RNA by vascular endothelial cells. J Neurosurg. 2001;94(6):961-971.
28.
Minamino T. , Mitsialis SA, Kourembanas S.Hypoxia extends the life span of vascular smooth muscle cells through telomerase activation. Mol Cell Biol. 2001;21(10):3336-3342.
29.
Fuster JJ, Andrés V.Telomere biology and cardiovascular disease. Circ Res.2006;99(11):1167-1180.
30.
Kimura M., Barbieri M., Gardner JP, et al. Leukocytes of exceptionally old persons display ultra-short telomeres. Am J Physiol Regul Integr Comp Physiol. 2007;293(6):R2210-R2217.
31.
Yamaguchi T. , Takahashi H., Harada Y., et al. Telomere shortening in human HL60 cells by treatment with deoxyguanosine analogs. Nucleic Acids Symp Ser (Oxf). 2004;48:187-188.
32.
Hornsby PJTelomerase and the aging process. Exp Gerontol. 2007;42(7):575-581.
33.
Graakjaer J. , Christensen R., Kolvraa S., Serakinci N.Mesenchymal stem cells with high telomerase expression do not actively restore their chromosome arm specific telomere length pattern after exposure to ionizing radiation. BMC Mol Biol. 2007;8:49.
34.
Joshua AM, Vukovic B., Braude I., et al. Telomere attrition in isolated high-grade prostatic intraepithelial neoplasia and surrounding stroma is predictive of prostate cancer. Neoplasia. 2007;9(1): 81-89.
35.
Lai SR, Cunningham AP, Huynh VQ, et al. Evidence of extratelomeric effects of hTERT and its regulation involving a feedback loop. Exp Cell Res. 2007 ;313(2):322-330.
