The purpose was to compare calf muscle hemoglobin oxygen saturation and exercise performance in hypercholesterolemic and normocholesterolemic patients with peripheral arterial disease. Hypercholesterolemic and normocholesterolemic patients had similar ankle/ brachial index (0.72 ± 0.24 vs 0.79 ± 0.28, [mean ± SD]; P = .334). Hypercholesterolemic patients had shorter initial claudication distance (214 ± 168 m vs 331 ± 185 m, P = .026), absolute claudication distance (391 ± 219 m vs 549 ± 211 m, P = .035), and lower calf muscle hemoglobin oxygen saturation at the occurrence of initial claudication distance (27 ± 21% vs 39 ± 20%; P = .013), and absolute claudication distance (26 ± 21% vs 36 ± 21%; P = .021). Hypercholesterolemia is associated with shorter walking distances and calf muscle hemoglobin oxygen saturation during exercise in patients limited by intermittent claudication.
Hirsch AT, Haskal ZJ, Hertzer NR, et al. ACC/AHA guidelines for the management of patients with peripheral arterial disease (lower extremity, renal, mesenteric, and abdominal aortic): a collaborative report from the American Associations for Vascular Surgery/Society for Vascular Surgery, Society for Cardiovascular Angiography and Interventions, Society for Vascular Medicine and Biology, Society of Interventional Radiology, and the ACC/AHA Task Force on Practice Guidelines (writing committee to develop guidelines for the management of patients with peripheral arterial disease)-summary of recommendations. J Vasc Interv Radiol. 2006;17(9): 1383-1398.
2.
Levine GN, Keaney JF Jr, Vita JACholesterol reduction in cardiovascular disease. Clinical benefits and possible mechanisms. N Engl J Med. 1995;332(8):512-521.
3.
Williams KJ, Tabas I.The response-to-retention hypothesis of early atherogenesis. Arterioscler Thromb Vasc Biol. 1995;15(5):551-561.
4.
Shaul PWEndothelial nitric oxide synthase, caveolae, and the development of atherosclerosis . J Physiol. 2003;547 (Pt 1):21-33.
5.
Pratico D.Antioxidants and endothelium protection. Atherosclerosis. 2005;181(2):215-224.
6.
Creager MA, Cooke JP, Mendelsohn ME, et al. Impaired vasodilation of forearm resistance vessels in hypercholesterolemic humans. J Clin Invest. 1990;86(1):228-234.
7.
Aronow WS, Nayak D., Woodworth S.Effect of simvistatin versus placebo on treadmill exercise time until the onset of intermittent claudication in older patients with peripheral arterial disease at 6 months and at 1 tear after treatment. Am J Cardiol . 2003;92:711-712.
Casavola C., Paunescu LA, Fantini S., Franceschini MA, Lugara PM, Gratton E.Application of near-infrared tissue oxymetry to the diagnosis of peripheral vascular disease. Clin Hemorheol Microcirc. 1999;21(3-4):389-393.
10.
Comerota AJ , Throm RC, Kelly P., Jaff M.Tissue (muscle) oxygen saturation (StO2): a new measure of symptomatic lower-extremity arterial disease. J Vasc Surg. 2003;38(4): 724-729.
11.
Watanabe T. , Matsushita M., Nishikimi N., Sakurai T., Komori K., Nimura Y.Near-infrared spectroscopy with treadmill exercise to assess lower limb ischemia in patients with atherosclerotic occlusive disease. Surg Today. 2004; 34(10):849-854.
12.
Pentecost MJ , Criqui MH, Dorros G., et al. Guidelines for peripheral percutaneous transluminal angioplasty of the abdominal aorta and lower extremity vessels. A statement for health professionals from a special writing group of the Councils on Cardiovascular Radiology, Arteriosclerosis, Cardio-Thoracic and Vascular Surgery, Clinical Cardiology, and Epidemiology and Prevention, the American Heart Association. Circulation. 1994;89(1): 511-531.
13.
Gardner AW, Skinner JS, Cantwell BW, Smith LKProgressive vs single-stage treadmill tests for evaluation of claudication . Med Sci Sports Exerc. 1991;23(4): 402-408.
14.
Weitz JI, Byrne J., Clagett GP, et al. Diagnosis and treatment of chronic arterial insufficiency of the lower extremities: a critical review. Circulation. 1996;94(11): 3026-3049.
15.
Expert Panel on Detection, Evaluation and Treatment of High Blood Cholesterol in Adults.Executive summary of the third report of the National Education Program (NCEP) Expert Panel on Detection, Evaluation and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA. 2001;285:2486-2497.
16.
Lohman TG, Roche AF, Martorell R, ed. Anthropometric Standardization Reference Manual. Champaign, IL: Human Kinetics Books; 1988.
17.
Regensteiner JG, Steiner JF, Panzer RJ, Hiatt WREvaluation of walking impairment by questionnaire in patients with peripheral arterial disease. J Vasc Med Biol . 1990;2:142-152.
18.
Gardner AWReliability of transcutaneous oximeter electrode heating power during exercise in patients with intermittent claudication. Angiology. 1997;48(3): 229-235.
19.
Gardner AW, Killewich LA, Katzel LI, et al. Relationship between free-living daily physical activity and peripheral circulation in patients with intermittent claudication. Angiology. 1999;50(4):289-297.
20.
Gardner AW, Skinner JS, Smith LKEffects of handrail support on claudication and hemodynamic responses to single-stage and progressive treadmill protocols in peripheral vascular occlusive disease . Am J Cardiol. 1991;68(1): 99-105.
21.
Feinberg RL , Gregory RT, Wheeler JR, et al. The ischemic window: a method for the objective quantitation of the training effect in exercise therapy for intermittent claudication. J Vasc Surg. 1992 ;16(2):244-250.
22.
Gardner AW, Sieminski DJ, Killewich LAThe effect of cigarette smoking on free-living daily physical activity in older claudication patients. Angiology. 1997 ;48(11):947-955.
23.
Gardner AWThe effect of cigarette smoking on exercise capacity in patients with intermittent claudication. Vasc Med. 1996;1(3):181-186.
24.
Mondillo S., Ballo P., Barbati R., et al. Effects of simvastatin on walking performance and symptoms of intermittent claudication in hypercholesterolemic patients with peripheral vascular disease. Am J Med. 2003;114(5):359-364.
25.
Mohler ER 3rd, Hiatt WR, Creager MACholesterol reduction with atorvastatin improves walking distance in patients with peripheral arterial disease. Circulation. 2003;108(12):1481-1486.
26.
Bauer TA, Brass EP, Hiatt WRImpaired muscle oxygen use at onset of exercise in peripheral arterial disease . J Vasc Surg. 2004;40(3):488-493.
