Efficacy of Topical Treatment with Aescin + Essential Phospholipids Gel in Venous Insufficiency and Hypertension

Abstract

Aescin and essential phospholipids (AEPL) in a gel was used in a microcirculatory model to assess the effects on skin perfusion in chronic venous insufficiency and severe venous hypertension. The aim of this efficacy study was to evaluate the efficacy of an AEPL gel on the microcirculation measuring transcutaneous skin PO2 and PCO2 in subjects with chronic venous insufficiency, venous hypertension (CVH), and venous microangiopathy. Transcutaneous PO2 and PCO2 were measured at the internal perimalleolar region. After 2 weeks of treatment with AEPL, all TcPO2 individual values were increased and all PCO2 values were decreased (p<0.05). Average values were significantly changed toward normal. Therefore, considering skin PO2 and PCO2 variations, local treatment with AEPL in areas of venous microangiopathy is very effective in improving skin perfusion and nutrition and, possibly, in preventing venous ulcerations.