Microcirculatory Efficacy of Topical Treatment with Aescin + Essential Phospholipids Gel on Transcutaneous PO2 in Venous Insufficiency

Abstract

A gel including aescin, essential phospholipids (EPL), and heparin (EG) has been used for many years for local treatment of venous, microcirculatory alterations (varicose veins, chronic venous insufficiency). Bruises, swelling, thrombophlebitis, and contusions are effectively treated with this compound. The aim of this study was the evaluation of the efficacy of the effects of an AEPL (aescin+EPL) gel on the microcirculation in subjects with chronic venous insufficiency, venous hypertension (CVH), and venous microangiopathy. Transcutaneous PO2 was measured at the perimalleolar region. After 2 weeks of treatment, all individual values (100%) were significantly increased (p<0.05). In all patients, PO2 increased, indicating a decrease in level of venous microangiopathy. Considering transcutaneous skin PO2, treatment with AEPL in areas of venous microangiopathy is beneficial in the prevention of ulceration and improves skin healing.

Get full access to this article

View all access options for this article.

References

Belcaro G

Nicolaides AN

Geroulakos G

et al

: Essaven gel—Review of experimental and clinical data. Angiology 52:S1-S4, 2001.

Incandela L

Belcaro G

Cesarone MR

: Microangiopathy and venous ulceration: Topical treatment with Essaven gel—A placebo-controlled, randomized study. Angiology 52:S17-S21, 2001.

Cesarone MR

De Sanctis MT

Incandela L

et al

: Microvascular changes in venous hypertension due to varicose veins after standardized application of Essaven gel—A placebo-controlled, randomized study. Angiology 52:S11-S16, 2001.

Belcaro G: Laser Doppler in venous hypertension (PhD thesis). University of London, 1996.

Bollinger A

Leu AJ

Hoffman U

et al

: Microvascular changes in venous disease: An update. Angiology 48:27-32, 1997.

De Santis MT

Cesarone MR

Incandela L

: Treatment of superficial vein thrombophlebitis of the arm with Essaven gel—a placebo-controlled, randomized study. Angiology 52:S63-S67, 2001.

Incandela L

Belcaro G

Nicolaides AN

et al

: Micro-circulation after standardized application of Essaven gel on normal skin—a placebo-controlled, randomized study. Angiology 52:S5-S10, 2001.