Chlamydia pneumoniae (CP) is a bacterium that in recent years has been investigated as an etiologic agent for atherosclerosis. It is a ubiquitous microorganism that has been isolated in various regions of the vascular system and its prevalence is about 10% in the patient population. This study involved a group of 43 patients (27 men, 16 women, mean age 68 years) who underwent carotid endarterectomy. About 9.3% of the patients yielded plaques that tested positive for the DNA genome of Chlamydia pneumoniae.
Ward ME: The immunobiology and immunopathology of chlamydial infections. APMIS103:769-796, 1995.
4.
Grayston JT, Kuo C-C., Wang SP, et al: A new Chlamydia Psittaci strain, TWAR, isolated in acute respiratory tract infections. N Engl J Med315:161-168, 1986.
5.
Kuo C-C., Coulson AS, Campbell LA, et al: Detection of Chlamydia pneumoniae in atherosclerotic plaques in the walls of arteries of lower extremities from patients undergoing bypass operation for arterial obstruction. J Vasc Surg26:29-31, 1997.
6.
Juvonen J., Juvonen T., Laurila A., et al: Demonstration of Chlamydia pneumoniae in the walls of abdominal aortic aneurysms. J Vasc Surg25:499-505, 1997.
7.
Grayston JT, Kuo C-C., Coulson AS, et al: Chlamydia pneumoniae (TWAR) in atherosclerosis of the carotid artery. Circulation92:3397-3400, 1995 .
8.
Jackson LA, Campbell LA, Schmidt RA, et al: Specificity of detection of Chlamydia pneumoniae in cardiovascular atheroma. AJP150:1785-1790, 1997 .
9.
Maas M., Krause E., Engel PM, et al: Endovascular presence of Chlamydia pneumoniae in patients with hemodynamically effective carotid artery stenosis. Angiology48:699-706, 1997.
10.
Wissler RW: Significance of Chlamydia pneumoniae (TWAR) in atherosclerotic lesions . Circulation92:3376, 1995.
11.
Kuo C-C., Campbell LA, Fukushi H., et al: Demonstration of Chlamydia pneumoniae in atherosclerotic lesions of coronary arteries. J Infect Dis167:841-849, 1993.
12.
Kuo C-C., Grayston JT, Campbell LA, et al: Chlamydia pneumoniae (TWAR) in coronary arteries of young (15 to 35 years) adults. Proc Natl Acad Sci USA92:6911-6914, 1995.
13.
Gupta S., Leatham EW, Carrington D., et al: Elevated Chlamydia pneumoniae antibodies, cardiovascular events, and azithromycin in male survivors of myocardial infarction. Circulation96:404-407, 1997.