Longer existing atherosclerotic lesions may contain calcifications; lamellar bone rarely develops within them. A 59-year-old man was referred with a progressive stroke. A high- grade stenosis of the left common carotid artery, formed by an ulcerating atherosclerotic plaque with a free-floating thrombus, was detected on angiography. An urgent endarterectomy was performed. Surprisingly this plaque contained pieces of lamellar bone, proved by histologic examination.
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References
1.
Boström K., Watson S., Horn C., et al: Bone morphogenetic protein expression in human atherosclerotic lesions. J Clin Invest91:1800-1809, 1993 .
2.
Janssens deVarebeke B., Van Osselaer G.: Late occlusion of a polytetrafluoroethylene femoropopliteal graft due to implant calcification and heterotopic ossification. Acta Chir Belg94:288-290, 1994.
3.
Bartosh R., Johnson W.: Limited dermal ossification: A case report. Orthop Rev17:169-172, 1988.
4.
Weisz G.: Ossifying surgical scar in Forestier's disease. Int Surg70:273, 1985.
5.
Frank R., Gerard P., Wise G.: Human penile ossification : A case report and review of the literature . Urol Radiol11:179-181, 1989.
6.
Byard R., Thomas M.: Osseous metaplasia within tumours. A review of 11 cases. Ann Pathol8:64-66, 1988.
7.
Ansari M., Sachs I., Max E., et al: Heterotopic bone formation in rectal carcinoma. Case report and literature review. Dig Dis Sci37:1624-1629, 1992.
8.
Bettendorf U. , Remmele W., Laaff H.: Bone formation by cancer metastases: Case report and review of literature. Virchows Archiv Pathol Anat Histol369 :359-365, 1976.
9.
Shepard J., Moore E., Templeton P., et al: Pulmonary intravascular tumor emboli: dilated and beaded peripheral pulmonary arteries at CT. Radiology187:797-801, 1993.
10.
Watson K., Ravindranath R., Lam T., et al: TGF-beta 1 and 25-hydroxycholesterol stimulate osteoblast-like vascular cells to calcify. J Clin Invest93:2106-2113, 1994.
11.
Schmid K., McSharry W., Pameijer C., et al: Chemical and physiochemical studies on the mineral deposits of the human atherosclerotic aorta. Atherosclerosis37:199-210, 1980.
12.
Boström K., Watson K., Stanford W., et al: Atherosclerotic calcification: Relation to developmental osteogenesis . Am J Cardiol75:88B-91B, 1995.
13.
Khouri R., Koudsi K., Reddi H.: Tissue transformation into bone in vivo: A potential practical application . JAMA266:1953-1955, 1991 .
