This study aimed to evaluate the prognostic value of the cholinesterase–prognostic nutritional index (ChE–PNI) score in patients undergoing curative colorectal resection for colorectal cancer.
Methods
This retrospective study included 628 patients who underwent curative colorectal resection for stage II/III CRC. Preoperative serum ChE levels and PNI were used to calculate the ChE–PNI score, and patients were categorized into 3 groups (score 0, 1, or 2). We investigated the association between the ChE–PNI score and survival outcomes.
Results
Among all patients, 88 (14%) were classified as the ChE–PNI score of 2. Multivariate analysis revealed that American Society of Anesthesiologists physical status ≥3 (P = .009), T stage 3-4 (P = .004), N stage 1-3 (P < .001), ChE–PNI = 2 (P = .031), and serum carcinoembryonic antigen ≥5.0 ng/ml (P = .002) were independent predictors of disease-free survival. While, age ≥65 (P = .027), Anesthesiologists physical status ≥3 (P < .001), N stage 1-3 (P = .013), and ChE-PNI = 2 (P = .005) were independent predictors of overall survival.
Conclusion
The ChE–PNI score is a novel, simple, and effective marker that independently predicts postoperative prognosis in patients with colorectal cancer.
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